Yan Li, PhD

Assistant Professor
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

yan.li@utsouthwestern.edu

Education

Graduate SchoolUniversity of New Orleans, Chemistry (2003)
Graduate SchoolNankai University, Chemistry (1994)
UndergraduateNankai University, Chemistry (1991)

Research Interests

Protein quantification
PTM analysis technology

Publications

Featured
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation

Mukherjee, S.; Keitany, G; Li, Y.; Wang, Y.; Ball, H. L.; Goldsmith, E. J.; Orth, K. , Science , 2006; (312 (5777)):1211-14

Featured
Fusion Peptide-Phospholipid Noncovalent Interactions As Observed by Nanoelectrospray FTICR-MS

Li, Y.; Heitz, F.; Le Grimellec, C.; and Cole, R. B. , Analytical Chemistry , 2005; (77):1556-1565

Featured
Mapping of Potential Gradients within the Electrospray Emitter

Li, Y.; Pozniak, B. P.; and Cole, R. B. , Analytical Chemistry , 2003; (75):6987-6994

Featured
Shifts in peptide and protein charge state distributions with varying spray tip orifice diameter in nano-electrospray FT-ICR mass spectrometry

Li Y, Pozniak BP, Cole RB , Analytical Chem , 2003; (75(21)):5739-46

AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling

Yarbrough ML, Li Y, Kinch LN, Grishin NV, Hall HL, Orth K , Science , January 2009; (323(5911)):269-72

The cell cycle as a therapeutic target against Trypanosoma brucei: Hesperadin inhibits Aurora kinase-1 and blocks mitotic progression in bloodstream forms

Jetton N, Rothberg KG, Hubbard JG, Wise J, Li Y, Ball HL, Ruben L , Mol Bicrobiol , April 2009; (72(2)):442-8

Direct mass spectrometry approaches to characterize polyphenol composition of complex samples

Fulcrand H, Mane C, Preys S, Mazerolles G, Bouchut C, Mazauric JP, Souquet JM, Meudec E, Li Y, Cole RB, Cheynier V. , Phytochemistry , April 2008;

VopA inhibits ATP binding by acetylating the catalytic loop of MAPK kinases

Trosky J.E., Li Y., Mukherjee S., Keitany G., Ball H., Orth K.. , J Biol Chem. , 2007; (282(47)):34299-305

Optimized proteomic analysis of a mouse model of cerebellar dysfunction using amine-specific isobaric tags

Hu, J.; Qian, J.; Borisov, O.; Pan, S.; Li, Y.; Liu, T.; Deng, L.; Wannemacher, K.; Kurnellas, M.; Patterson, C.; Elkabes, S.; Li, H. , Proteomics , 2006; (6):4321-4334

Professional Associations/Affiliations

American Society for Mass Spectrometry