Aktar Ali, PhD

Assistant Professor
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

aktar.ali@utsouthwestern.edu

Biography

EDUCATION:

 1992 Chittagong University, Bangladesh BSc (Hons) Chemistry

1994 Chittagong University, Bangladesh MSc Inorganic Chemistry

1999 Niigata University of Pharmacy, Japan PhD Pharmaceutical Science

 

POSTDOCTORAL TRAINING:

1999-2000 Niigata University of Pharmacy, Japan.

2000-2005 New York University (NYU) School of Medicine, New York.

 

AWARDS AND HONORS:

1995-1997 Student fellowship of AIEJ (Association of International Education in Japan)

1997-1999 Student fellowship of Niigata University of Pharmacy

 

PROFESSIONAL ASSOCIATIONS/AFFILIATIONS:

American Association for Cancer Research

Society for Free Radical Biology and Medicine

 

Research Interests

Angiogenesis
Cyclooxygenase 2
GBM invasion
Hypoxia and and hypoxia inducible factor

Publications

Featured
SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor

Ali MA, Choy H, Habib AA, Saha D , Neoplasia , May 2007; (9):370-381

Featured
Downregulation of major histocompatibility complex antigens in invading glioma cells: stealth invasion of the brain

Zagzag D, Salnikow K, Chiriboga L, Yee H, Lan L, Ali MA, Garcia R, Demaria S, Newcomb EW , Lab Invest. , March 2005; (85):328-341

Featured
Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1alpha expression in human glioma cells by a proteasome-independent pathway: implications for in vivo therapy

Newcomb EW, Ali MA, Schnee T, Lan L, Lukyanov Y, Fowkes M, Miller DC, Zagzag D , Neuro Oncology , July 2005; (7):225-235

Featured
Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor

Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali MA, Melamed J, Semenza GL. , Cancer Research , July 2005; (65):6178-6188

Featured
The cyclin-dependent kinase 2 inhibitor down-regulates interleukin-1beta-mediated induction of cyclooxygenase-2 expression in human lung carcinoma cells

Mukhopadhyay P, Ali MA, Nandi A, Carreon P, Choy H, Saha D , Cancer Research , February 2006; (66):1758-1766

SNS-032 prevents tumor cell induced angiogenesis by inhibition vascular endothelial growth factor.

Ali MA, Choy H, Habib AA and Saha D. , Neoplasia , May 2007; (9):370-381

Noscapine inhibits hypoxia mediated HIF-1a expression and angiogenesis in vitro.

Newcomb EW, Lukyanov E, Schnee T, Ali MA Lan L and Zagzag D , International Journal of Oncology , May 2006; (28):1121-1130

Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1 expression in human glioma cells by a proteasome-independent pathway: Implications for in vivo therapy

Newcomb EW, Ali MA, Schnee T, Lan L, Lukyanov Y, Fowkes M, Miller DC, Zagzag D , Neuro Oncology , July 2005; (7):225-235

The cyclin-dependent kinase 2 inhibitor down-regulates interleukin-1beta-mediated induction of cyclooxygenase-2 expression in human lung carcinoma cells

Mukhopadhyay P, Ali MA, Nandi A, Carreon P, Choy H and Saha D , Cancer Research , February 2006; (66):1758-1766

Hypoxia-Inducible Factor 1 and VEGF upregulate CXCR4 in Glioblastoma: Implication for Angiogenesis.

Zagzag D, Lan L, Ali MA, Schnee T, Lukyanov E, Yee H, Newcomb EW. , Laboratory Investigation , December 2006; (86):1221-1232