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David Boothman, PhD
Endowed Title: Robert B. and Virginia Payne Professorship in Oncology
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Office Phone: 214-648-4190
Office Fax: 214-648-7084
Biography
Boothman, David A.
Professor, Associate Director for Translational Research
University of Michigan B.S. 1981 Microbiology
University of Miami Ph.D. 1986 Microbiology & Immunology
1986-1989 Postdoctoral Fellow, Mol. Pharm. & Cell Growth and Reg., Harvard Medical School, Dana-Farber Cancer Inst.
1989-1993 Assistant Professor, Dept. Radiation Oncology, Div. Cancer Biology, U Michigan
1993-1996 Assistant Professor, Dept. of Human Oncology, U W-Madison
1996-1998 Associate Professor, Vice Chairman of Basic Research, Human Oncology, U W-Madison
1998-2001 Associate Professor, Radiation Oncology, Pharmacology, Case Western Reserve University
2001-2005 Professor, Radiation Oncology, Pharmacology, Case Western Reserve University
2002-2005 Associate Dir Basic Research, Distinguished Inv. Award, Case Western Reserve University
2005-present Robert and Virginia Payne Professor of Oncology, UT Southwestern
2005-present Co-Director, Program in Cell Stress and Cancer Nanomedicine, UT Southwestern
2005-present Associate Dir. Translational Research, UT Southwestern
1993-1999 NIH, Radiation Biol., Chem. Path B Study Section
1997-2002 NIH ET-2 Study Section
2002-2005 DT Study Section
1997-Present DOD Prostate and Breast Cancer
1997-Present DOE/NASA Low Dose IR Effects
1999-Present NIH Program Project/SPORE Grants
2005-Present NIH Traineeship Awards
2007-Present RTB Study Section
HONORS
1985 AACR-Upjohn Travel Award
1985 Dir., Eastern Student Research Forum (AMA)
1988 NRSA Tumor Biology Fellowship
1993-2005 Distinguished Investigator Award, Case Western Reserve University
2005-Pres Robert B. and Virginia Payne Professor of Oncology
Recent peer-reviewed pubs (from >100):
Shannan, B, Seifert, M, Boothman, DA, Tilgen, W, and Reichrath, J. Clusterin over-expression modulates proapoptotic and antiproliferative effects of 1,25(OH)(2)D(3) in prostate cancer cells in vitro. J. Ster Biochem Mol Biol. 2007; 103: 721-725.
Bey EA, Bentle MS, Reinicke KE, Dong Y, Yang CR, Girard L, Minna JD, Bornmann WG, Gao J, Boothman DA. An NQO1-and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone. PNAS 2007; 104: 11832-7.
Choi, EK, Terai, K, Ji, I-M, Kook, Y, Park, K, Oh, E, Griffin, R, Lim, B, Lee, D, Boothman, DA, Loren, M, Song, CW, and Park, HJ. Radiation-induced up-regulation of NAD(P)H:quinone oxidoreductase (NQO1) potentiates the effect of bioreductive β-lapachone against cancer cells. Neoplasia 2007; 9(8): 634-642.
Bentle MS, Reinicke KE, Dong Y, Bey EA, Boothman DA. Non-homologous end joining is essential for cellular resistance to beta-lapachone. Cancer Res. 2007; 67(14): 6936-45.
Blanco E, Bey EA, Dong Y, Weinberg BD, Sutton DS, Boothman DA, Gao J. Beta-lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells. J Con Rel 2007; 122(3): 365-74. Epub 2007 Apr 29.
Gomez J, Gama V, Yoshida T, Sun W, Hayes P, Leskov K, Boothman DA, Matsuyama S. Bax-inhiiting peptides derived from Ku70 and cell-penetrating pentapeptides. Biochem. Soc. Trans. 2007; 53: 797-801.
Wagner, MW, Li, LS, Morales, JC, Galindo, CL, Garner, HR, Bornmann, WG, and Boothman, DA. Role of c-Abl in MMR-dependent G2 arrest responses. JBC 2008; 283: 21382-21393.
Li, LS, Morales, JC, Hwang, A, Wagner, MW, and Boothman, DA. DNA mismatch repair-dependent activation of c-Abl/p73a/GADD45a-mediated apoptosis. JBC 2008; 283: 21394-21403.
Suzuki, M and Boothman, DA Modulating stress-induced premature senescence (SIPS) for therapy. J. Rad Res., 2008; 49: 105-112.
Education
| Graduate School | University of Miami, Microbiology (1986) |
| Undergraduate | University of Michigan-Ann Arbor, Microbiology (1980) |
Research Interests
Publications
1. Boothman DA, Meyers M, Lee SW. , Proceedings of the National Academy of Sciences , October 1993; (90):7200-7204
5. Pink JJ, Planchon SM, Tagliarino C, Wuerzberger-Davis SM, Varnes ME, Siegel D, Boothman DA. , Journal of Biological Chemistry , November 2000; (275):5416-5422
Leskov KS, Klokov DY, Li J, Kinsella TJ, Boothman DA , J Biol Chem , March 2003; (278(13)):11590-600
Criswell T, Beman M, Araki S, Leskov K, Cataldo E, May LD, Boothman DA , J Biol Chem , April 2005; (280(14)):14212-21
Sawada M, Sun W, hayes P, Keskov K, Boothman DA, Matuyama S , Nat Cell Biol , April 2003; (5(4)):320-9
Nasongkla N, Shuai X, Ai H, Weinberg BD, Pink J, Boothman DA, Jingming G , Angew Chem Int Ed Engl , November 2004; (43(46)):6323-6327
Li, LS, Morales, JC, Hwang, A, Wagner, MW, and Boothman, DA. , Journal of Biological Chemistry , May 2008; (283):21394-21403
Wagner, MW, Li, LS, Morales, JC, Galindo, CL, Garner, HR, Bornmann, WG, and Boothman, DA. , Journal of Biological Chemistry , May 2008; (283):21382-21393
Meyers M, Mqazurek A, Schmutte C, Fishel R, Boothman DA , J Biol Chem , February 2005; (280(7)):5516-26
Bey EA, Bentle MS, Reinicke KE, Dong Y, Yang CR, Girard L, Minna JD, Bornmann WG, Gao J, Boothman DA. , Proceedings of the National Academy of Sciences , August 2007; ((28)/104:):11832-11837
Related Links
Honors/Awards
Case Western Reserve University (2000)
Radiation Research Society (1999)
American Assoc. for Cancer Research (1985)