James Amatruda, MD, PhD

Assistant Professor
Endowed Title: Horchow Family Scholar in Pediatrics 2005-2009
Pediatrics, Internal Medicine, Molecular Biology
Graduate Program: Cancer Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

james.amatruda@utsouthwestern.edu

To make an appointment, call 214-730-KIDS (5437).

Biography

Harvard University

A.B.

June, 1986

Biochemistry

Washington University

M.D.

May, 1993

Medicine

Washington University

Ph.D.

May, 1993

Cell Biology

Brigham and Women’s Hospital, Boston, MA

Residency

1993-1996

Internal Medicine

Dana-Farber/Partners Cancer Care

Fellowship

1997-1999

Medical Oncology

Boston Children’s/Harvard Medical School

Post-doc

1999-2004

 Hematology-Oncology

Education

FellowshipChildren's Hospital of Boston (2004)
FellowshipDana-Farber Cancer Institute (1999)
FellowshipConsglio Nazionale delle Ricerche (1997)
ResidencyBrigham and Women's Hospital (1996)
Medical SchoolWashington University School of Medicine (1993)

Research Interests

Animal Models of Cancer
Cancer Genetics
DNA Damage Response
Testicular Cancer
Zebrafish

Publications

Featured
A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis.

Leacock SW, Basse AN, Chandler GL, Kirk AM, Rakheja D, Amatruda JF, Disease models & mechanisms, 2011 Oct;

Featured
High-resolution array CGH identifies common mechanisms that drive embryonal rhabdomyosarcoma pathogenesis.

Paulson V, Chandler G, Rakheja D, Galindo RL, Wilson K, Amatruda JF, Cameron S, Genes, chromosomes & cancer, 2011 Jun; 50 (6):397-408

Featured
Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish.

Neumann JC, Chandler GL, Damoulis VA, Fustino NJ, Lillard K, Looijenga L, Margraf L, Rakheja D, Amatruda JF, Proceedings of the National Academy of Sciences of the United States of America, 2011 Aug; 108 (32):13153-8

Featured
Bone morphogenetic protein signalling activity distinguishes histological subsets of paediatric germ cell tumours.

Fustino N, Rakheja D, Ateek CS, Neumann JC, Amatruda JF, International journal of andrology, 2011 Aug; 34 (4 Pt 2):e218-33

Featured
Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.

Jacob LS, Wu X, Dodge ME, Fan CW, Kulak O, Chen B, Tang W, Wang B, Amatruda JF, Lum L, Science signaling, 2011 ; 4 (157):ra4

Featured
Zebrafish models of germ cell tumor.

Neumann JC, Lillard K, Damoulis V, Amatruda JF, Methods in cell biology, 2011 ; 105:3-24

Featured
Identification of a heritable model of testicular germ cell tumor in the zebrafish.

Neumann JC, Dovey JS, Chandler GL, Carbajal L, Amatruda JF, Zebrafish, 2009 Dec; 6 (4):319-27

Analysis of cell proliferation, senescence, and cell death in zebrafish embryos.

Verduzco D, Amatruda JF, Methods in cell biology, 2011 ; 101:19-38

Honors/Awards

Outstanding Teacher, MS1 Class

(2011)

Outstanding Teacher, MS1 Class

(2010)

Health Care Heroes Award, Dallas Business Journal

(2009)

Outstanding Teacher, MS1 Class

(2009)

Outstanding Teacher, MS1 Class

(2007)

Horchow Family Endowed Scholar in Pediatrics

(2005)

William Guy Forbeck Research Foundation Scholar

(2003)

Arnold Dunne Award

(1994)

Alpha Omega Alpha

(1993)