Thomas Carroll, PhD

Associate Professor
Internal Medicine, Molecular Biology
Graduate Program: Genetics and Development

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-4187
Office Fax: 214-648-1196

thomas.carroll@utsouthwestern.edu

Education

Graduate SchoolUniversity of Texas at Austin, Zoology (1999)
UndergraduateUniversity of California-Davis, Biology (1992)

Research Interests

Cancer
Cell polarity
Developmental Biology
Morhpogenesis
Stem/progenitor cells

Publications

Featured
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis.

Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford JB, Carroll TJ. , Nature Genetics , July 2009; (41(7)):793-799

Featured
Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state.

Marose TD, Merkel CE, McMahon AP, Carroll TJ. , Dev. Biol. , February 2008; (314(1)):112-26

Featured
Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system.

Carroll TJ, Park JS, Hayashi S, Majumdar A, McMahon AP. , Developmental Cell , August 2005; (9 (2)):283-92

Featured
Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.

Karner CM, Das A, Ma Z, Self M, Chen C, Lum L, Oliver G, Carroll TJ, Development (Cambridge, England), 2011 Apr; 138 (7):1247-57

Featured
Tankyrase is necessary for canonical Wnt signaling during kidney development.

Karner CM, Merkel CE, Dodge M, Ma Z, Lu J, Chen C, Lum L, Carroll TJ, Developmental dynamics : an official publication of the American Association of Anatomists, 2010 Jul; 239 (7):2014-23

Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development.

Kobayashi A, Valerius MT, Mugford JW, Carroll TJ, Self M, Oliver G, McMahon AP. , Cell Stem Cell , August 2008; (3(2)):169-81

The Leucine Zipper Putative Tumor Suppressor 2 Protein LZTS2 Regulates Kidney Development.

Peng Y, Clark C, Luong R, Tu WH, Lee J, Johnson DT, Das A, Carroll TJ, Sun Z, The Journal of biological chemistry, 2011 Nov; 286 (46):40331-42

Planar cell polarity in kidney development and disease.

Carroll TJ, Das A, Organogenesis, 2011 Jul; 7 (3):180-90

PCP goes organic.

Carroll TJ, Organogenesis, 2011 Jul; 7 (3):163-4

Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development.

Smeeton J, Zhang X, Bulus N, Mernaugh G, Lange A, Karner CM, Carroll TJ, Fässler R, Pozzi A, Rosenblum ND, Zent R, Development (Cambridge, England), 2010 Oct; 137 (19):3233-43

Honors/Awards

A.S.N. Gottschalk Career Development Award

(2005)

A.H.A. Scientist Development Grant

Professional Associations/Affiliations

American Society for Nephrology

Society for Developmental Biology