Andrew Feranchak, MD

Associate Professor
Endowed Title: Willis C. Maddrey, M.D., Professorship in Liver Disease
Pediatrics
Graduate Program: Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

drew.feranchak@utsouthwestern.edu

To make an appointment, call 214-730-KIDS (5437).

Biography

Dr. Andrew Feranchak is a graduate of the University of Notre Dame and the University of Pittsburgh Medical School. He completed his internship and residency in Pediatrics at The Children’s Hospital in Pittsburgh and his fellowship in Pediatric Gastroenterology, Hepatology, and Nutrition at the University of Colorado Health Sciences and Children’s Hospital Denver. Dr. Feranchak’s clinical interests include cholestatic liver disease, assessment of nutritional and fat-soluble vitamin status, and gastrointestinal and liver complications of cystic fibrosis. His basic research interests include understanding the mechanisms of bile formation, biliary secretion, and liver cell volume regulation. He is the winner of the American Liver Foundation Postdoctoral Research Fellowship Award, the North American Society Pediatric Gastroenterology and Nutrition Fellow Research Award, the Children’s Digestive Health and Nutrition Foundation Silver Anniversary Award, and the Regal Award for excellence in gastroenterology and liver research. He is presently an Associate Professor in the Department of Pediatrics at UT Southwestern Medical Center and the Children’s Medical Center, Dallas, Texas.

Education

Research FellowUniversity of Colorado Health Science Center, Hepatology (1999)
FellowshipUniversity of Colorado Health Sciences Center (1999)
ResidencyChildren's Hospital of Philadelphia (1995)
Medical SchoolUniv. of Pittsburgh School of Medicine (1992)

Research Interests

Biophysical characterization of membrane ion channels
Cell volume regulation
Cholestatic liver disease
Hepatobiliary transport
Mechanisms of bile formation

Publications

Featured
Initiation of purinergic signaling by exocytosis of ATP-containing vesicles in liver epithelium

Feranchak AP, Lewis MA, Kresge C, Sathe M, Bugde A, Luby-Phelps K, Antich P, Fitz JG , J Biol Chem , 2010; (285):8138-47

Featured
Calcium-dependent regulation of secretion in biliary epithelial cells: the role of apamin-sensitive SK channels

Feranchak AP, Doctor RB, Troetsch M, Brookman K, Johnson SM, Fitz JG , Gastroenterol , 2004; (127):903-13

Featured
P38 MAP Kinase modulates liver cell volume through inhibition of membrane Na+ permeability

Feranchak AP, Berl T, Capasso J, Wojtaszek PA, Han J, Fitz JG , J Clin Invest , 2001; (108):1495-1504

Featured
Prospective long-term study of fat-soluble vitamin status in children with cystic fibrosis identified by newborn screen

Feranchak AP, Sontag MK, Wagener JS, Hammond KB, Accurso FJ, Sokol RJ , J Pediatr , 1999; (135):601-10

Featured
The lipid products of phosphoinositide 3-kinase contribute to regulation of cholangiocyte ATP and chloride transport.

Feranchak AP, Roman RM, Salter KD, Toker A, Fitz JG , J Biol Chem , 1999; (274):30979-30986

Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by extracellular nucleotides, in biliary epithelium.

29. Dutta AK, Khimji AK, Kresge C, Bugde A, Dougherty M, Esser V, Ueno Y, Glaser SS, Alpini G, Rockey DC, Feranchak AP , J Biol Chem , January 2011; (286):766-776

ATP release and P2 receptor-mediated secretion in small and large mouse cholangiocytes

Woo K, Sathe M, Kresge C, Esser V, Ueno Y, Venter J, Glaser S, Alpini G, Feranchak AP , Hepatology , 2010; (52):1819-1828

Identification and functional characterization of the intermediate conductance Ca2+-activated K+ channel (IK-1) in biliary epithelium

Dutta AK, Khimji AK, Sathe M, Kresge C, Parameswara V, Esser V, Rockey DC, Feranchak AP , Am J Physiol Gastrointest Liver Physiol , 2009; (297):G1009-G1018

Extracellular nucleotides stimulate Cl- currents in biliary epithelia through receptor mediated IP3 and Ca2+ release

Dutta AK, Woo K, Doctor RB, Fitz JG, Feranchak AP , Am J Physiol Gastrointest Liver Physiol , 2008; (295):G1004-G1015

Fluid-flow induces mechanosensitive ATP release, calcium signaling, and Cl- transport in biliary epithelial cells through a PKCzeta-dependent mechanism

Woo K, Dutta A, Patel V, Kresge C, Feranchak AP , J Physiol , 2008; (586):2779-2798

Professional Associations/Affiliations

American Association for the Study of Liver Disease

American Gastroenterological Association

American Physiological Society

North American Society of Pediatric Gastroenterology and Nutrition

Society of Pediatric Research