Lawrence Lum, PhD

Assistant Professor
Endowed Title: Virginia Murchison Linthicum Scholar in Medical Research 2004-2008
Cell Biology
Graduate Program: Cancer Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-2570
Office Fax: 214-648-8694

lawrence.lum@utsouthwestern.edu

Education

Graduate SchoolCornell University Medical College (1999)

Research Interests

Hedgehog and Wnt
signal transduction
signaling networks

Publications

Featured
Prevalence of off-target effects in Drosophila RNAi screens

Ma Y, Creanga A, Lum L, and Beachy PA , Nature , September 2006; (443(7109)):359-63

Featured
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

Lum L, Zhang C, Oh S, Mann R, Von Kessler DP, Taipale J, Weis-Garcia F, Gong R, Wang B, Beachy PA , Mol Cell , November 2003; (12):1261-1274

Featured
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells

Lum L, Yao S, Mozer B, Rovescalli A, Von Kessler D, Nirenberg M, Beachy PA , Science , March 2003; (299 (5615)):2039-45

Featured
A genome-wide RNAi screen for Wnt/beta-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

Tang W, Dodge M, Gundapaneni D, Michnoff C, Roth M, Lum L , PNAS , July 2008; (105(28)):9697-9702

Featured
Small molecule-mediated disruption of Wnt-dependent signal transduction in tissue regeneration and cancer

Chen B, Dodge M, Tang W, Lu J, Ma Z, Fan C-W, Wei S, Hao W, Kilgore J, Williams N, Roth M, Amatruda J, Chen C, and Lum L. , Nature Chemical Biology , January 2008;

Deconstructing the Hedgehog pathway in development and disease

Jacob L and Lum L , Science , October 2007; (318):66-8

Minimizing the risk of reporting false positives in large-scale RNAi screens

Echeverri CJ, Beachy PA, Baum B, Boutros M, Buchholz F, Chanda SK, Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL, Kiger A, Linsley PS, Lum L, Ma Y, Mathey-Prevot B, Root DE, Sabatini DM, Taipale J, Perrimon N, Bernards R , Nat Methods , October 2006; (3(10)):777-9

The ihog cell-surface proteins bind Hedgehog and mediate pathway activation

Yao S, Lum L, and Beachy PA , Cell , April 2006; (125(2)):343-57

Honors/Awards

American Cancer Society Research Scholar

(2007)

Virginia Murchison Linthicum Scholar in Medical Research

University of Texas Southwestern Medical Center (2005)

Life Sciences Research Foundation Fellowship

Post doctoral Fellowship (2000)

Dean’s Research Award

Cornell University Medical College (1994)

Grace Fimognari Memorial Award

University of California, Berkeley (1993)