David Chen, PhD

Professor
Endowed Title: David A. Pistenmaa, M.D., Ph.D., Distinguished Professorship in Radiation Oncology
Radiation Oncology
Graduate Program: Cancer Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-7600

david.chen@utsouthwestern.edu

Education

Graduate SchoolUniversity of Missouri-Columbia (1978)

Research Interests

DNA damage responses induced by HZE particles in human cells
Structural Cell Biology of DNA Repair Machines
The role of DNA-PK in DNA double-strand break repair

Publications

Featured
The endless tale of non-homologous end-joining

47. Weterings E, Chen DJ. , Cell Research , 2008; (18):114-24

Featured
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

Uematsu N, Weterings E, Yano K, Morotomi-Yano K, Jakob B, Taucher-Scholz G, Mari PO, van Gent DC, Chen BP, Chen DJ , J Cell Biol , 2007; (177):219-29

Featured
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is

Chan DW, Chen BP, Prithivirajsingh S, Kurimasa A, Story MD, Qin J, Chen DJ , Genes Dev , 2002; (16):2333-8

Featured
Werner syndrome protein is regulated and phosphorylated by DNA-dependent

Yannone SM, Roy S, Chan DW, Murphy MB, Huang S, Campisi J, Chen DJ , J Biol Chem. , 2001; (276):38242-8

Featured
Live cell imaging of XLF and XRCC4 reveals a novel view of protein assembly in the non-homologous end-joining pathway.

51. Yano KI, Chen DJ , Cell Cycle , ; (7):1321-5

Ku recruits XLF to DNA double-strand breaks

48. Yano K, Morotomi-Yano K, Wang SY, Uematsu N, Lee KJ , EMBO , 2008; (9):91-6

Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break

Chen BP, Uematsu N, Kobayashi J, Lerenthal Y, Krempler A, Yajima H, Lobrich M, Shiloh Y, Chen DJ , J Biol Chem , 2007; (282):6582-7

Role of non-homologous end joining (NHEJ) in maintaining genomic integrity

Burma S, Chen BP, Chen DJ , DNA Repair , 2006; (5):1042-8

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

Perry JJ, Yannone SM, Holden LG, Hitomi C, Asaithamby A, Han S, Cooper PK, Chen DJ, Tainer JA , Nat Struct Mol Biol , 2006; (13):414-22

Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks

Chen BP, Chan DW, Kobayashi J, Burma S, Asaithamby A, Morotomi-Yano K, Botvinick E, Qin J, Chen DJ , J Biol Chem , 2005; (280):14709-15

Honors/Awards

NIH MERIT Research Award

(2003)

Professional Associations/Affiliations

American Association for the Advancement of Science

American Association of cancer Research

American Society for Therapeutic Radiology and Oncology

American Society of Cell Biology

Radiation Research Society