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Lu Le, MD, PhD
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Office Phone: 214-645-2400
To make an appointment, call 214-645-8300.
Biography
Dr. Le received his Ph.D. degree in Microbiology, Immunology and Molecular Genetics, and a medical degree (M.D.) from the Medical Scientist Training Program at the University of California, Los Angeles (UCLA). He completed an Internship in Internal Medicine at UCLA/St. Mary Medical Center, residency training in Dermatology and a postdoctoral fellowship in Cancer Biology from University of Texas Southwestern Medical Center. He is board certified by the American Board of Dermatology. Dr. Le sees patients in the Dermatology clinic and at the UTSW Comprehensive Neurofibromatosis clinic.
As an investigator in Cancer Biology, his primary research goals are to 1) elucidate mechanisms that initiate and drive human cancer, 2) generate robust animal models to better understand disease pathogenesis and 3) develop novel therapeutic targets for human cancers. A related goal is to translate basic scientific findings in the laboratory into human clinical trials. His principal scientific interests include identifying the cell origin of tumorigenesis and elucidating the roles of tumor microenvironment in cancer development. His laboratory utilizes Neurofibromatosis Type I, a common tumor predisposition human genetic disorder, as a model to address these two fundamental questions of Cancer Biology as well as elucidating cutaneous nervous system development and regeneration.
Education
| Fellowship | UT Southwestern Graduate School of Biomed Sciences, Cancer Biology (2009) |
| Residency | UT Southwestern Medical Center, Dermatology (2007) |
| Internship | Saint Mary's Medical Center-Long Beach, Internal Medicine (2004) |
| Medical School | University of California, Los Angeles (2003) |
| Graduate School | University of California - Los Angeles (2002) |
Research Interests
Publications
Le, L.Q., Shipman, T., Burns, D.K., Parada, L.F. , Cell Stem Cell , May 2009; (4 (5)):453-463
Le, L.Q. (Corresponding author), Liu, C., Shipman, T., Chen, Z., Suter, U., Parada, L.F. , Cancer Research , 2011; (71(13)):4686-95
Brown, R., Klesse, L., Le, L.Q. , Journal of Investigative Dermatology , 2010; (130 (9)):2167-9
Le, L.Q., Parada, L.F. , Oncogene , 2007; (26(32)):4609-4616
Le, L.Q., Kabarowski, J., Wong, S., Nguyen, K., Gambhir, S., Witte, O.N. , Cancer Cell , 2002; (1(4)):381-391
Le, L.Q., Kabarowski, J., Weng, Z., Satterthwaite, A., Harvill, E., Jensen, E., Miller, J.F. and Witte, O.N. , Immunity , 2001; (14(5)):561 - 571
Kabarowski, J.H.S., Feramisco, J.D., Le, L.Q., Gu, J.L., Luoh, S-W., Simon, M.I., and Wite, O.N. , Proc. Natil. Acad. Sci. USA , 2000; (97):12109 - 12114
Honors/Awards
(2010)
(2009)
(2008)
(2008)
(2008)