Beth Levine, MD

Professor
Endowed Title: Charles Cameron Sprague Distinguished Chair in Biomedical Science
Internal Medicine, Microbiology
Graduate Program: Cancer Biology
Molecular Microbiology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

beth.levine@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Education

FellowshipJohns Hopkins University School of Medicine, Infectious Disease (1992)
ResidencyMount Sinai School of Medicine, Internal Medicine (1989)
InternshipMount Sinai School of Medicine, Internal Medicine (1987)
Medical SchoolWeill Cornell Medical College (1986)

Research Interests

Autophagy in Cell Death Regulation and Cancer Biology
Autophagy in Innate Immunity against Intracellular Pathogens
Host-Pathogen Interactions

Publications

Featured
Bcl-2 anti-apoptotic proteins inhibit Beclin 1-dependent autophagy.

Pattingre S, Tassa A, Qu X, Liang XH, Packer M, Schneider MD, Levine B. , Cell , September 2005; (122):927-939

Featured
Autophagy genes are essential for dauer development and lifespan extension in C. elegans.

Melendez A, Talloczy Z, Seaman M, Eskelinen E-L, Hall DH, Levine B. , Science , September 2003; (301):1387-1391

Featured
HSV-1 ICP34.5 confres neurovirulence by targeting the Beclin 1 autophagy protein.

Orvedahl A, Alexander D, Talloczy Z, Leib DA, Levine B. , 2007 , March 2007; (1):23-35

Featured
Autophagy gene-dependent clearance of apoptotic cells during embryonic development.

Qu X, Zou Z, Sun Q, Luby-Phelps K, Cheng P, Hogan RN, Gilpin C, Levine. , Cell , March 2007; (128):931-946

Featured
Induction of autophagy and inhibition of tumorigenesis by beclin 1.

Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B , Nature , December 1999; (402):672-676

Autophagy fights disease through cellular self-digestion.

Mizushima, N., Levine, B., Cuervo, A.M. and Klionsky, D. , Nature , 2008; (451):1069-1075

p53: The Janus of autophagy?

Levine, B. and Abrams, J. , Nature Cell Biology , 2008; (10):637-639

Bcl-2 family members: dual regulators of apoptosis and autophagy.

Levine, B., Sinha, S. , Autophagy , 2008; (4):600-606

Autophagy and Viral Neurovirulence

Orvedahl, A., Levine, B. , Cellulary Microbiology , 2008; (10/9):1747-1756

Honors/Awards

Howard Hughes Medical Institute

Investigator (2008)

Ellison Medical Foundation

Senior Scholars Award (2004)

American Cancer Society

Outstanding Achievement & Contributions to Cancer Research (2003)

American Society of Clinical Investigation

Elected Member (2000)

31st Mallinckrodt Scholar Award

(1999)