Greg Fitz, MD

EVP for Academic Affairs, Provost and Dean
Professor
Endowed Title: Nadine and Tom Craddick Distinguished Chair in Medical Science
Atticus James Gill, M.D., Chair in Medical Science
Office of the Dean - Southwestern Medical School, Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

greg.fitz@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Education

FellowshipUniversity of California at San Francisco, Gastroenterology (1985)
ResidencyUniversity of California at San Francisco, Internal Medicine (1983)
InternshipUniversity of California at San Francisco, Internal Medicine (1980)
Medical SchoolDuke University School of Medicine (1979)

Research Interests

Biliary secretion
Cellular mechanisms of insulin resistance
Epithelial ion channels
Purinergic signaling

Publications

Featured
Evidence for multidrug resistance-1 P-glycoprotein-dependent regulation of cellular ATP permeability.

Roman RM, Lomri N, Braunstein G, Feranchak AP, Simeoni LA, Davison AK, Mechetner E, Schwiebert EM, Fitz JG, The Journal of membrane biology, 2001 Oct; 183 (3):165-73

Featured
p38 MAP kinase modulates liver cell volume through inhibition of membrane Na+ permeability.

Feranchak AP, Berl T, Capasso J, Wojtaszek PA, Han J, Fitz JG, The Journal of clinical investigation, 2001 Nov; 108 (10):1495-504

Featured
Insulin stimulates membrane conductance in a liver cell line: evidence for insertion of ion channels through a phosphoinositide 3-kinase-dependent mechanism.

Kilic G, Doctor RB, Fitz JG, The Journal of biological chemistry, 2001 Jul; 276 (29):26762-8

Featured
Hepatocellular ATP-binding cassette protein expression enhances ATP release and autocrine regulation of cell volume.

Roman RM, Wang Y, Lidofsky SD, Feranchak AP, Lomri N, Scharschmidt BF, Fitz JG, The Journal of biological chemistry, 1997 Aug; 272 (35):21970-6

Featured
Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation.

Wang Y, Roman R, Lidofsky SD, Fitz JG, Proceedings of the National Academy of Sciences of the United States of America, 1996 Oct; 93 (21):12020-5

Volume-sensitive tyrosine kinases regulate liver cell volume through effects on vesicular trafficking and membrane Na+ permeability.

Feranchak AP, Kilic G, Wojtaszek PA, Qadri I, Fitz JG, The Journal of biological chemistry, 2003 Nov; 278 (45):44632-8

Cholangiocytes exhibit dynamic, actin-dependent apical membrane turnover.

Doctor RB, Dahl R, Fouassier L, Kilic G, Fitz JG, American journal of physiology. Cell physiology, 2002 May; 282 (5):C1042-52

Heterotrimeric G-proteins activate Cl- channels through stimulation of a cyclooxygenase-dependent pathway in a model liver cell line.

Kilic G, Fitz JG, The Journal of biological chemistry, 2002 Apr; 277 (14):11721-7

Cystic fibrosis transmembrane conductance regulator facilitates ATP release by stimulating a separate ATP release channel for autocrine control of cell volume regulation.

Braunstein GM, Roman RM, Clancy JP, Kudlow BA, Taylor AL, Shylonsky VG, Jovov B, Peter K, Jilling T, Ismailov II, Benos DJ, Schwiebert LM, Fitz JG, Schwiebert EM, The Journal of biological chemistry, 2001 Mar; 276 (9):6621-30

ClC-2 chloride channels contribute to HTC cell volume homeostasis.

Roman RM, Smith RL, Feranchak AP, Clayton GH, Doctor RB, Fitz JG, American journal of physiology. Gastrointestinal and liver physiology, 2001 Mar; 280 (3):G344-53

Honors/Awards

MERIT Award

National Institutes of Health (2002)

Association of American Physicians

(2001)

Waterman Chair in Liver Research

(1996)

Eugene Stead Award for Excellence in Teaching

Duke University (1991)

American Society for Clinical Investigation

Best Doctors in America 2001, 2002, 2003

Professional Associations/Affiliations

American Association for the Study of Liver Disease

American Federation for Clinical Research

American Gastroenterological Association

American Society for Clinical Investigation

Association of American Physicians