Debabrata Saha, PhD

Assistant Professor
Radiation Oncology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-7600

debabrata.saha@utsouthwestern.edu

Education

Graduate SchoolUniversity of Nebraska at Lincoln (1997)

Research Interests

Role of Cycloxygenase-2 in radiation and chemo-resistance.
Role of small molecule inhibitors as radio-sensitizers

Publications

Featured
Potential radiation-sensitizing effect of semisynthetic epothilone B in human lung cancer cells.

Kim JC, Kim JS, Saha D, Cao Q, Shyr Y and Choy H , Radiotherapy and Oncology , September 2003; (68):305-313

Featured
Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells.

Saha D, Datta PK, Sheng H, Morrow JD, Wada M, Moses HL and Beauchamp RD , Neoplasia , December 1999; (6):508-517

Featured
Resistance to transforming growth factor-beta occurs in the presence of normal Smad activation.

Berger DH, Feng XH, Yao J, Saha D, Beauchamp RD, Lin X , Surgery , August 2002; (132):310-316

Featured
Oncogenic ras represses transforming growth factor-beta /Smad signaling by degrading tumor suppressor Smad4.

Saha D, Datta PK and Beauchamp RD , Journal of Biological Chemistry , August 2001; (276):29531-29537

Featured
Potential for combined modality therapy of cyclooxygenase inhibitors and radiation.

Saha D and Choy H , Prog Exp Tumor Res , 2003; (37):193-209

The antiangiogenic agent SU5416 down-regulates phorbol ester-mediated induction of cyclooxygenase 2 expression by inhibiting nicotinamide adenine dinucleotide phosphate oxidase activity

Saha D, Sekhar M, Cao C, Morrow JD, Choy H and Freeman ML , Cancer Research , October 2003; (63):6920-6927

Enhancement of radiation effects by combined docetaxel and flavopiridol treatment in lung cancer cells.

Kim JC, Saha D, Cao C and Choy H , Radiotherapy and Oncology , May 2004; (71):213-221

COX-2 inhibitor as a radiation enhancer: new strategies for the treatment of lung cancer.

Saha D, Pyo H and Choy H , American Journal of Clinical Oncology , August 2003; (26):S70-S74

The Cyclin Dependent Kinase 2 Inhibitor Downregulates Interleukin 1-Beta Mediated Induction of Cyclooxygenase 2 Expression in Human Lung Carcinoma Cells

Mukhopadhyay P, Ali MA, Nandi A, Carreon P, Choy H and Saha D , Accepted for publication in Cancer Research , ; (In Press)

Correlation of HER1/EGFR expression and degree of radiosensitizing effect of the HER1/EGFR-tyrosine kinase inhibitor erlotinib

Kim JC, Ali MA, Nandi A, Mukhopadhyay P, Choy H, Cao C and Saha D , Indian Journal of Biochemistry and Biophysics , ; (In Press):In Press

Honors/Awards

Recipient of FAMRI Young Clinical Investigator Award

(2005)

Recipient of American Association for Cancer Research Award

(2004)

Recipient of FAMRI Young Clinical Scientist Award

(2002)

Recipient of National Research Service Award

(2000)