Weichun Lin, PhD

Associate Professor
Endowed Title: Effie Marie Cain Scholar in Medical Research 2003-2007
Neuroscience
Graduate Program: Neuroscience

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-1800
Office Fax: 214-648-1801

weichun.lin@utsouthwestern.edu

Biography

1985 Xiamen University, Xiamen, China, BS, Biology

1996 State University of New York, Albany, NY, PhD, Neuroscience

2003 The Salk Institute, La Jolla, CA, Research Associate

Education

Graduate SchoolSUNY at Albany (1996)

Research Interests

Neurodegeneration
Synapse formation

Publications

Featured
Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors.

Fujun Chen, Yun Liu, Yoshie Sugiura, Paul D. Allen, Ronald G. Gregg and Weichun Lin , Nature Neuroscience , March 2011;

Featured
Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction.

Fujun Chen, Yoshie Sugiura, Kalisa Galina Myers, Yun Liu, and Weichun Lin , Proceedings of the National Academy of Sciences, U.S.A , January 2010; (107):1636-1641

Featured
Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism.

Weichun Lin, Bertha Dominguez, Jiefei Yang, Prafulla Aryal, Eugene P. Brandon, Fred H. Gage and Kuo-Fen Lee , Neuron , 2005; (46):569-579

Featured
Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse.

Weichun Lin, Robert Burgess, Bertha Dominguez, Samuel Pfaff, Joshua Sanes and Kuo-Fen Lee , Nature , March 2001; (410):1057-1064

Featured
Essential roles of acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning

Yun Liu, Daniel Padgett, Masazumi Takahashi, Hongqiao Li, Ayaz Sayeed, Russell W. Teichert, Baldomero M. Olivera, Joseph McArdle, William N. Green, and Weichun Lin , Development , June 2008; (135):1957-1967

Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors.

Fujun Chen, Yun Liu, Yoshie Sugiura, Paul D. Allen, Ronald G. Gregg and Weichun Lin , Nature Neuroscience , March 2011;

The role of Synaptobrevin1/VAMP1 in Ca2+-triggered neurotransmitter release at the mouse neuromuscular junction.

Yun Liu, Yoshie Sugiura and Weichun Lin , Journal of Physiology , 2011; (589):1603-1618

Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction.

Fujun Chen, Yoshie Sugiura, Kalisa Galina Myers, Yun Liu, and Weichun Lin , Proceedings of the National Academy of Sciences, U.S.A , January 2010; (107):1636-1641

Abnormal development of the neuromuscular junction in Nedd4-deficient mice.

Yun Liu, Oppenheim, R. W., Sugiura, Y., and Weichun Lin , Developmental Biology , June 2009; (330):153-166

Essential roles of acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning

Yun Liu, Daniel Padgett, Masazumi Takahashi, Hongqiao Li, Ayaz Sayeed, Russell W. Teichert, Baldomero M. Olivera, Joseph McArdle, William N. Green, and Weichun Lin , Development , June 2008; (135):1957-1967

Honors/Awards

Mallinckrodt Scholar

Edward Mallinckrodt, Jr. Foundation (2006)

Effie Marie Cain Scholar in Medical Research

U.T. Southwestern Endowed Scholar Award, 2003-2007 (2003)

Postdoctoral Fellowship

Le Ducq Foundation (2000)