Joseph Ready, PhD

Associate Professor
Endowed Title: Southwestern Medical Foundation Scholar in Biomedical Research 2003-2007
Biochemistry
Graduate Program: Biological Chemistry

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-0313
Office Fax: 214-648-0320

joseph.ready@utsouthwestern.edu

Biography

I was born in Fayetteville, NC and grew up outside of Philadelphia, PA. As an undergraduate at the University of North Carolina I worked in the laboratories of Paul Kropp and, at the National Institutes of Environmental Health Sciences, Masahiko Negishi. I completed my graduate studies at Harvard University in 2001 under the direction of Eric Jacobsen, studying epoxide ring opening reactions. I then moved to Yale University for a postdoc with John Wood where I focused on total synthesis. I joined the faculty at UT Southwestern in 2003, and my research group currently focuses on natural products synthesis, medicinal chemistry and synthetic methodology.

Lab website: http://www4.utsouthwestern.edu/readylab/index.htm

Education

Graduate SchoolHarvard University, Chemistry (2001)
UndergraduateUniversity of North Carolina at Chapel Hill, Chemistry (1996)

Research Interests

Discovery and application of new chemical reactions; synthesis of biologically active small molecules

Publications

Featured
Enantioselective total synthesis of (-)-kibdelone C.

Butler JR, Wang C, Bian J, Ready JM, Journal of the American Chemical Society, 2011 Jul; 133 (26):9956-9

Featured
Synthesis of Cyclopentenones from Cyclopropanes and Silyl Ynol Ethers

Qi, X.; Ready, J.M. , Angew. Chem. Int. Ed. , 2008; (47):7068-7070

Featured
Directed Hydrozirconation of Propargylic Alcohols

Zhang, D.H.; Ready, J.M. , J. Am. Chem. Soc. , 2007; (129):10288-10289

Featured
Enantioselective Total Synthesis of (+)- and (-)-Nigellamine A2

Bian, J.; Wingerden, M. V.; Ready, J. M. , J. Am. Chem. Soc. , 2006; (128):7428-7429

Featured
Iron-Catalyzed Carbometalation of Propargylic and Homopropargylic Alcohols

Zhang, D. H.; Ready, J. M. , J. Am. Chem. Soc. , 2006; (128):15050-15051

Development of Proneurogenic, Neuroprotective Small Molecules

MacMillan, K.S.; McKnight, S.L.; Pieper, A.A.; De Brabander, J. K.; Ready, J.M. , J. Am. Chem. Soc. , 2011; (133):1428-1437

Titanium-Mediated Oxidative Arylation of Homoallylic Alcohols

Lee, K.S.; Ready, J.M. , Angew. Chem. Int. Ed. , 2011; (50):2111-2114

Allenes in Asymmetric Catalysis: Asymmetric Ring Opening of meso-Epoxides Catalyzed by Allene-Containing Phosphine Oxides

Pu, X.; Qi, X.; Ready, J. M , J. Am. Chem. Soc. , 2009; (131):10364-10365

Direct and Stereospecific Synthesis of Allenes via Reduction of Propargylic Alcohols with Cp2Zr(H)Cl

Pu, X.; Ready, J. M. , J. Am. Chem. Soc. , 2008; (130):10874-10875

Preparation of Substituted Enol Derivatives from Terminal Alkynes and thier Synthetic Utility

Debergh, J. R.; Spivey, K. M.; Ready, J. M. , J. Am. Chem. Soc. , 2008; (130):7828-7829

Honors/Awards

Alfred P. Sloan Foundation Fellow

(2009)

Amgen Young Investigator Award

(2007)

NSF CAREER Award

(2006)

Southwestern Medical Center Scholar in Biomedical Research

(2003)

NIH Postdoctoral Fellowhsip

(2001)