Roger Chan, PhD

Associate Professor
Otolaryngology - Head and Neck Surgery
Graduate Program: Biomedical Engineering

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-0386
Office Fax: 214-648-9122

roger.chan@utsouthwestern.edu

Biography

Dr. Chan is interested in both basic and applied studies of the human larynx at many different levels. In particular, the focus is on vocal fold tissue mechanics and biorheology, and their relationships with voice acoustics and laryngeal physiology. Another area of emphasis is tissue engineering and regenerative medicine, where various types of extracellular matrix scaffolds are being developed as tissue replacements for surgical applications.

Our laboratory projects involve the use of cell culture models, animal models, physical models and computer models of the larynx.

Education

Graduate SchoolUniversity of Iowa (1998)

Research Interests

Biomaterials for surgical applications
Laryngeal physiology, acoustics, and biomechanics
Solid mechanics (soft tissue mechanics)
Tissue engineering and regenerative medicine
Viscoelasticity and biorheology

Publications

Featured
The importance of hyaluronic acid in vocal fold biomechanics

Chan RW, Gray SD, Titze IR , Otolaryngology--Head and Neck Surgery , June 2001; (124(6)):607-614

Featured
Hyaluronic acid (with fibronectin) as a bioimplant for the vocal fold mucosa

Chan RW, Titze IR , Laryngoscope , July 1999; (109(7)):1142-1149

Featured
Viscoelastic shear properties of human vocal fold mucosa: Theoretical characterization based on constitutive modeling

Chan RW, Titze IR , Journal of the Acoustical Society of America , January 2000; (107(1)):565-580

Featured
A simple-shear rheometer for linear viscoelastic characterization of vocal fold tissues at phonatory frequencies.

Chan RW, Rodriguez ML , Journal of the Acoustical Society of America , 2008; (124):1207-1219

Featured
A biodegradable, acellular xenogeneic scaffold for regeneration of the vocal fold lamina propria.

Xu CC, Chan RW, Tirunagari N , Tissue Engineering , 2007; (13 (3)):551-566

Relative contributions of collagen and elastin to elasticity of the vocal fold under tension.

Chan RW, Fu M, Young L, Tirunagari N , Annals of Biomedical Engineering , 2007; (35):1471-1483

Dependence of phonation threshold pressure on vocal tract acoustics and vocal fold tissue mechanics.

Chan RW, Titze IR , Journal of the Acoustical Society of America , 2006; (119):2351-2362

Biomechanics of fundamental frequency regulation: Constitutive modeling of the vocal fold lamina propria.

Chan RW, Siegmund T, Zhang K , Logopedics Phoniatrics Vocology , ; ((in press).)

The human umbilical vein with Wharton’s jelly as an allogeneic, acellular construct for vocal fold restoration.

Chan RW, Rodriguez ML, McFetridge PS , Tissue Engineering Part A , ; ((in press).)

A bovine acellular scaffold for vocal fold reconstruction in a rat model.

Xu CC, Chan RW, Weinberger DG, Efune G, Pawlowski KS , Journal of Biomedical Materials Research Part A , ; ((in press).)

Honors/Awards

Keynote Address

Advances in Quantitative Laryngology Conference, Karolinska Institute, Stockholm, Sweden (2008)

Lecturer

The Mohs Lecture by Placon, Rheology Research Center, University of Wisconsin-Madison, Madison, Wisconsin (2005)

Professional Associations/Affiliations

Acoustical Society of America

International Society of Biomechanics

International Society of Biorheology

Society of Rheology

Tissue Engineering and Regenerative Medicine International Society