Haydn Ball, PhD

Associate Professor
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

haydn.ball@utsouthwestern.edu

Education

Graduate SchoolUniversity of London - England (1993)
UndergraduateUniversity of London - England (1982)

Research Interests

Expressed and Native Protein Lligation
Mass Spectrometry
Peptide Chemistry
Protein Identification by Mass Spectrometry
Protein Sequencing

Publications

Featured
Yersinia YopJ acetylates critical Ser/Thr residues on MKKs and IKKb blocking the innate immune response

38. Mukherjee, S., Keitany, G., Wang, Y., Li, Y., Ball, H. L., Goldsmith, E. J. and Orth, K. , Science , 2006; (312):1211-1214

Featured
Nicastrin functions as a gamma-secretase substrate receptor.

36. Shah, S., Lee, S. F., Tabuchi, K., Hao, Y. H., Yu, C., LaPlant, Q., Ball, H., Dann, C. E., Sudhof, T. and Yu, G , Cell , 2005; (122):435-447

Featured
Engineering the prion protein using chemical synthesis.

Ball, H.L., King, D., Cohen, F.E., Prusiner, S.B., and Baldwin, M.A. , J. Peptide Res. , 2001; (58):357-388

Featured
A synthethic peptide causes prion disease in transgenic mice.

Kaneko, K., Ball, H.L., Willie, H, Zhang, H., Groth, D., Torchias M., Tremblay, P., Safar, J., Prusiner, S.B., DeArmond, S.J., Baldwin, M.A., and Cohen, F.E. , J. Biol. Chem. , 2000; (295):997-1007

Featured
Chemical protein synthesis and purification: A methodology.

Ball, H.L., and Mascagni, P. , Int. J. Peptide Protein Res. , 1996; (48):31-47

Novel reversible biotinylated probe for the selective enrichment of phosphorylated peptides from complex mixtures

Jalili PR, Ball HL , J Am Soc Mass Spectrom , May 2008; (19(5)):741-50

AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling

Yarbrough ML, Li Y, Kinch LN, Grishin NV, Ball HL, Orth K , Science , January 2009; (323(5911)):269-72

Post-translational modifications corresponding to 42 Da ? Study of acetylation on Ser/Thr/Tyr/Lys and trimethylation on Lys using electrospray tandem mass spectrometry

Li, Y and Ball H.L. , Int. J. of mass Spectrometry , 2009; (281):24-30

Reversible biotinylated probe for the selective enrichment of phosphopeptides from complex biological mixtures.?

Jalili P.R. and Ball, H.L. , J. Am. Soc. Mass Spectrom. , 2008; (19):741-750

Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice.

Safar, J.G., Scott, M., Monaghan, J., Deering, C., Didorenko, S., Vergara, J., Ball, H.L., Legname, G., Leclerc, E., Solforosi, L., Serban, H., Groth, D., Burton, D.R., Prusiner, S.B. and Williamson, R.A. , Nat. Biotechnol. , 2002; (20):1147-1150

Professional Associations/Affiliations

American Peptide Society

American Society for Mass Spectrometry