Ion Bobulescu, MD

Instructor
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

alexandru.bobulescu@utsouthwestern.edu

Education

Graduate SchoolCarol Davila University Bucharest, Romania, Medicine (2000)
UndergraduateSf. Sava National College Bucharest, Romania, Biology (1994)

Research Interests

Integrative physiology
Na+/H+ exchange across lipid bilayers
Proximal tubule pathophysiology
Renal ion transport
Renal physiology

Publications

Featured
Renal lipid metabolism and lipotoxicity.

Bobulescu IA, Current opinion in nephrology and hypertension, 2010 Jul; 19 (4):393-402

Featured
Acute Regulation of Renal Na+/H+ Exchanger NHE3 by Dopamine: Role of Protein Phosphatase 2A.

Bobulescu IA, Quiñones H, Gisler SM, Di Sole F, Hu MC, Shi M, Zhang J, Fuster DG, Wright N, Mumby M, Moe OW, American journal of physiology. Renal physiology, 2010 Feb;

Featured
Reduction of renal triglyceride accumulation: effects on proximal tubule Na+/H+ exchange and urinary acidification.

Bobulescu IA, Dubree M, Zhang J, McLeroy P, Moe OW, American journal of physiology. Renal physiology, 2009 Nov; 297 (5):F1419-26

Featured
Luminal Na(+)/H (+) exchange in the proximal tubule.

Bobulescu IA, Moe OW, Pflügers Archiv : European journal of physiology, 2009 May; 458 (1):5-21

Featured
Effect of renal lipid accumulation on proximal tubule Na+/H+ exchange and ammonium secretion.

Bobulescu IA, Dubree M, Zhang J, McLeroy P, Moe OW, American journal of physiology. Renal physiology, 2008 Jun; 294 (6):F1315-22

Featured
Na+/H+ exchangers in renal regulation of acid-base balance.

Bobulescu IA, Moe OW, Seminars in nephrology, 2006 Sep; 26 (5):334-44

Featured
Na+/H+ exchangers: physiology and link to hypertension and organ ischemia.

Bobulescu IA, Di Sole F, Moe OW, Current opinion in nephrology and hypertension, 2005 Sep; 14 (5):485-94

Featured
Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosis.

Bobulescu IA, Dwarakanath V, Zou L, Zhang J, Baum M, Moe OW, American journal of physiology. Renal physiology, 2005 Oct; 289 (4):F685-91

The reduction of Na/H exchanger-3 protein and transcript expression in acute ischemia-reperfusion injury is mediated by extractable tissue factor(s).

Di Sole F, Hu MC, Zhang J, Babich V, Bobulescu IA, Shi M, McLeroy P, Rogers TE, Moe OW, Kidney international, 2011 Oct; 80 (8)

Effect of metabolic acidosis on neonatal proximal tubule acidification.

Twombley K, Gattineni J, Bobulescu IA, Dwarakanath V, Baum M, American journal of physiology. Regulatory, integrative and comparative physiology, 2010 Nov; 299 (5):R1360-8

Honors/Awards

UT Southwestern Graduate School of Biomedical Sciences

Haberecht Wildhare-Idea Research Award (2009)

American Society of Nephrology

Carl W. Gottschalk Research Scholar Award (2008)

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research

Postdoctoral Fellowship Award (2005)

National Kidney Foundation

Postdoctoral Fellowship Award (2003)

Professional Associations/Affiliations

American Physiological Society

(2007)

American Heart Association, Council on Kidney in Cardiovascular Disease

(2006-2008)

American Society of Human Genetics

(2006-2007)

American Association for the Advancement of Science

(2005-2007)

American Society of Nephrology

(2002)