Qing Lu, PhD

Associate Professor
Endowed Title: Southwestern Medical Foundation Scholar in Medical Research 2002-2006
Developmental Biology, Molecular Biology
Graduate Program: Cancer Biology
Neuroscience

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-1951
Office Fax: 214-648-1960

qrichard.lu@utsouthwestern.edu

Biography

Graduate School Rutgers University-UMDNJ, Ph.D.  Biochemistry (1997)
Graduate School

USTC/Chinese Academic Sinica, Institute of Chemistry (1991)

Undergraduate Beijing Normal University,  Biochemistry (1988)

Education

Graduate SchoolRutgers University New Brunswick (1997)

Research Interests

Epigenetic and Chromatin remodeling control of myelinating cell differentiation
Glioma formation/glioma initiating cells
GPCR signaling in glial development and diseases
MicroRNAs in oligodendrocyte myelination
Transcriptional regulation of neural stem cell differentiation/gliogenesis

Publications

Featured
MicroRNA-mediated control of oligodendrocyte differentiation

Zhao, X., He, X., Han, X., Yu, Y., Ye, F., Chen, Y., Hoang, T., Xu, X., Mi, Q.S., Xin, M., Wang, F., Appel, B. and Lu, Q.R. , Neuron , March 2010; (65):612-626

Featured
HDAC1 and HDAC2 Regulate Oligodendrocyte Differentiation By Disrupting β-Catenin-TCF Interaction

Ye F, Chen Y, Hoang T, Montgomery RL, Zhao XH, Bu H, Hu T, Taketo MM, van Es JH, Clevers H, Hsieh J, Bassel-Duby R, Olson EN, Lu QR , Nature Neuroscience , July 2009; (v12):829-838

Featured
HDAC-mediated Deacetylation of NF-κB is Critical for Schwann cell Myelination

Ying Chen, Haibo Wang, Sung Ok Yoon, Xiaomei Xu, Michael Hottiger, Haesun Kim, Eric N. Olson, and Q. Richard Lu , Nature Neuroscience , April 2011; (2011 Apr;14(4):437-41.)

Featured
Dual-mode Modulation of Smad Signaling by Smad-interacting Protein Sip1 is Required for Myelination in the CNS

Weng, Q., Y. Chen1, H. Wang, X. Xu, B. Yang, Q. He, W. Shou, Y. Chen, Y. Higashi, V. van den Berghe, E. Seuntjens, S. Kernie, P. Bukshpun, E. Sherr, D. Huylebroeck, Lu Q.R. , Neuron, 2011; (In press)

Featured
The oligodendrocyte-specific G-protein coupled receptor GPR17 is a cell intrinsic timer of myelination

Chen, Y. H. Wu, S. Wang, H. Koito, J. Li, J. Hoang, F. Ye, S. S. Escobar, A. Gow, H. A. Arnett, B. D. Trapp, N. J. Karandikar, J. Hsieh and Q. R. Lu , Nature Neuroscience , 2009; (12):1398-1406

Featured
Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection.

Lu, Q.R., Sun, T., Zhu, Z., Ma, N., Garcia, M., Stiles, C.D. and Rowitch, D. , Cell , 2002; (109):75-86

Sonic Hedgehog-Regulated Oligodendrocyte Lineage Genes Encoding bHLH Proteins in the Mammalian Central Nervous System.

Lu, Q.R., Yuk, D., Alberta, J.A., Zhu, Z., Pawlitzky, I., Chan, J., McMahon, A. P., Stiles, C. D. and Rowitch, D. H. , NEURON , 2000; (25):317-329

Honors/Awards

Basil O’connor scholar from March of Dimes

(2004)

Harry Weaver Neuroscience Scholar from NMSS

(2003)

The Best 'Mature' Scientific Study Award from Dana-Farber Cancer Institute

(2002)

Fellowship Award from the Charles A. King Trust and the Medical Foundation

(2001)

National Research Service Award Fellow from NIH

(1998)