Darryl Miles, MD

Assistant Professor
Pediatrics
Download Curriculum Vitae

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

darryl.miles@utsouthwestern.edu

To make an appointment, call 214-730-KIDS (5437).

Biography

My academic aim is to investigate the pathophysiology and long-term neurodevelopmental outcome after acquired brain injury in children. During my fellowship and as a junior faculty member, I used a transgenic mouse model to investigatye the endogenous capability of neural stem and progenitor cells to remodel the brain after injury.  We found that progenitor cells within the hippocampus, a central structure for learning and memory, could recover and replace damaged neurons after hypoxic-ischemic injury.

I have transitioned to a clinical and transplational appraoch to understanding CNS injury and recovery.  I am the lead investigator for an 5 year prospective cohort study sponsored by the Perot Center for Brain and Nerve Injury.  In this study we are investigating the genetic and clinical factors affecting neurodevelopmental outcome in children after traumatic brain injury (TBI).  We are currently analyzing how the the injury patterns on acute magnetic resonance imaging (MRI) and computed tomography (CT) imaging can help predict long-term conginitive function.  Hopefully, this will lead to a better understanding of TBI in children and how the childhood brain responds and recovers after acute injury.

Education

FellowshipUT Southwestern Medical Center at Dallas, Pediatric Critical Care Medicine (2005)
ResidencyUniversity of California at San Francisco, Pediatrics (2000)
InternshipUniversity of California at San Francisco, Pediatrics (1998)
Medical SchoolUniversity of California, San Francisco (1997)

Research Interests

MRI imaging Biomarkers of Neuronal Injury
Neural Stem Cells
Traumatic Brain Injury

Publications

Featured
Patterns of hematopoietic lineage involvement in children with neurofibromatosis type 1 and malignant myeloid disorders

Miles DK, Freedman MH, Stephens K, Pallavicini M, Sievers EL, Weaver M, Grunberger T, Thompson P, Shannon KM. , Blood , December 1996; (88(11)):4314-4320

Featured
Hypoxic-ischemic brain injury activates early hippocampal stem/progenitor cells to replace vulnerable neuroblasts

Miles DK., Kernie SG. , Hippocampus , April 2008; (18(8)):793-806

The Basic Helix-Loop-Helix Transcription Factor Olig2 Is Critical for Reactive Astrocyte Proliferation after Cortical Injury

Miles DK, Chen Y, Hoang T, Shi J, Hurlock E, Kernie SG, Lu R. , Journal of Neuroscience , October 2008; (28(43)):10983-10989

Injury induced neurogenesis in Bax- deficient mice: evidence for regulation by voltage-gated potassium channels

Shi J., Miles D.K., Orr B.A., Massa S.A., Kernie S.G , European Journal of Neuroscience , June 2007; (Vol. 25):pp. 3499-3512

Brief exposure to hyperoxia depletes the glial progenitor pool and impairs functional recovery after hypoxic-ischemic brain injury

Koch JD, Miles DK, Gilley JA, Yang CP, Kernie SG. , Journal of Cerebral Blood Flow and Metabolism , July 2008; (28(7)):1294-306

Activation of neural stem and progenitor cells after brain injury

Miles D.K., Kernie S.G. , Progress in Brain Research , Fall 2006; (Vol. 157):187-198

Honors/Awards

Conferred Thesis Dissertation

Presented by the University of California San Francisco (1996)

Dean’s Prize for Research

Presented by the University of California San Francisco (1996)

Western Society of Pediatric Research Lowell Glasgow Award

Presented by the University of California San Francisco (1995)

Magna cum Laude

San Jose State University (1993)

Minority Access to Research Careers Fellowship

San Jose State University (1993)

Professional Associations/Affiliations

National Neurotrauma Society

Society of Critical Care Medicine

Society of Neuroscience