Michihisa Umetani, PhD

Assistant Professor
Pediatrics, Pharmacology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

michihisa.umetani@utsouthwestern.edu

Education

Graduate SchoolUniversity of Tokyo - Japan, Biology (2000)
Graduate SchoolUniversity of Tokyo - Japan, Agriculture (1993)
UndergraduateUniversity of Tokyo - Japan, Agriculture (1991)

Research Interests

Regulation of estrogen receptor function by oxysterol 27-hydroxycholesterol
Role of cholesterol metabolites in cardiovascular and metabolic diseases
Role of nuclear receptors in vascular cells

Publications

Featured
27-Hydroxycholesterol: the first identified endogenous SERM.

Umetani M, Shaul PW, Trends in endocrinology and metabolism: TEM, 2011 Apr; 22 (4):130-5

Featured
27-Hydroxycholesterol is an endogenous Selective Estrogen Receptor Modulator (SERM)

Dusell, CD., Umetani, M., Shaul, PW., Mangelsdorf, DJ., and McDonnell, DP. , Mol. Endocrinol. , 2008; (22):65-77

Featured
27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen

Umetani, M., Domoto, H., Gormley, AK., Yuhanna, IS., Cummins, CL., Javitt, NB., Korach, KS., Shaul, PW., and Mangelsdorf, DJ. , Nat. Med. , 2007; (13):1185-1192

The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling.

Li T, Holmstrom SR, Kir S, Umetani M, Schmidt DR, Kliewer SA, Mangelsdorf DJ, Molecular endocrinology (Baltimore, Md.), 2011 Jun; 25 (6):1066-71

Non-nuclear estrogen receptor signaling in the endothelium.

Wu Q, Chambliss K, Umetani M, Mineo C, Shaul PW, The Journal of biological chemistry, 2011 Apr; 286 (17):14737-43

Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice.

Chambliss KL, Wu Q, Oltmann S, Konaniah ES, Umetani M, Korach KS, Thomas GD, Mineo C, Yuhanna IS, Kim SH, Madak-Erdogan Z, Maggi A, Dineen SP, Roland CL, Hui DY, Brekken RA, Katzenellenbogen JA, Katzenellenbogen BS, Shaul PW, The Journal of clinical investigation, 2010 Jul; 120 (7):2319-30

The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.

DuSell CD, Nelson ER, Wang X, Abdo J, Mödder UI, Umetani M, Gesty-Palmer D, Javitt NB, Khosla S, McDonnell DP, Endocrinology, 2010 Aug; 151 (8):3675-85

The Endogenous Selective Estrogen Receptor Modulator 27-Hydroxycholesterol Is a Negative Regulator of Bone Homeostasis.

Dusell, CD., Nelson, ER., Wang, X., Abdo, J., Modder, UI., Umetani M., Gesty-Palmer, D., Javitt, NB., Khosla, S., and McDonnell, DP. , Endocrinol. , 2010; (doi:10.1210/en.2010-0080)

Identification of a hormonal basis for gallbladder filling.

Choi M, Moschetta A, Bookout AL, Peng L, Umetani M, Holmstrom SR, Suino-Powell K, Xu HE, Richardson JA, Gerard RD, Mangelsdorf DJ, Kliewer SA, Nature medicine, 2006 Nov; 12 (11):1253-5

Wilms’ tumor 1-associating protein regulated G2/M transition through stabilization of cyclin A2 mRNA

Horiuchi, K.*, Umetani, M.*, Minami, T., Okayama, H., Takada, S., Yamamoto, M., Aburatani, H., Reid, PC., Housman, DE., Hamakubo, T., and Kodama, T. (* contributed equally) , Proc. Natl. Acad. Sci. USA , 2006; (103):17278-17283

Honors/Awards

American Diabetes Association

Junior Faculty Award (2011)

American Heart Association

Travel Award for Young Investigators (2010)

Kern Aspen Lipid Conference

Early Career Investigator Award (2010)

UTSW O’Brien Kidney Research Center

Pilot and Feasibility Award (2009)

Uehara Memorial Fellowship

(2002)

Professional Associations/Affiliations

American Diabetes Association

American Heart Association