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Steven Kliewer, PhD
Endowed Title: Nancy B. and Jake L. Hamon Distinguished Chair in Basic Cancer Research
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Office Phone: 214-645-6304
Office Fax: 214-645-6305
Biography
Steven Kliewer earned his BS in biochemistry from Brown University in 1985 and his PhD in molecular biology from the University of California, Los Angeles in 1990. From 1990-1993, he was a postdoctoral fellow in the laboratory of Dr. Ronald Evans at the Salk Institute for Biological Studies in La Jolla, CA, where he began his studies on orphan nuclear receptors. During this period, he discovered the central role that the retinoid receptor RXR plays as an obligate heterodimer partner for the vitamin D, thyroid hormone, retinoic acid, and peroxisome proliferator-activated receptors.
In 1993, he joined Glaxo, Inc. in Research Triangle Park, NC, where he founded a scientific group devoted to exploiting orphan nuclear receptors as drug discovery targets. Among his achievements at Glaxo was the discovery that the fatty acid receptor PPAR-gamma is the molecular target for the antidiabetic glitazone class of drugs, which ultimately led to the clinical development compound farglitazar. He also discovered the xenobiotic receptor PXR and showed that it is responsible for an important class of drug-drug interactions. A practical consequence of this work is that new drugs can be screened efficiently for harmful interactions with other medications.
In 2002, he joined the faculty at UT Southwestern, where he is currently Professor of Molecular Biology and Pharmacology and holds the Hamon Distinguished Chair in Basic Cancer Research. His research is focused on nuclear receptors and their roles in xenobiotic and lipid metabolism.
Education
| Graduate School | University of California-Los Angeles (1990) |
| Undergraduate | Brown University (1985) |
Research Interests
Publications
Kliewer, S.A., Lehmann, J.M., and Willson, T.M. , Science , 1999; (284):757-760
Kliewer, S.A., Moore, J.T., Wade, L., Staudinger, J.L., Watson, M.A., Jones, S.A., McKee, D.D., Oliver, B.B., Willson, T.M., Zetterstrom, R.H., Perlmann, T., and Lehmann, J.M. , Cell , 1998; (92):73-82
Lehmann, J.M., Moore, L.B., Smith-Oliver, T.A., Wilkison, W.O., Willson, T.M., and Kliewer, S.A. , J. Biol. Chem , 1995; (270):12953-12956
Kliewer, S.A., Lenhard, J.M., Willson, T.M., Patel, I., Morris, D.C., and Lehmann, J.M. , Cell , 1995; (83):813-819
Kliewer, S.A., Umesono, K., Mangelsdorf, D.J., and Evans, R.M. , Nature , 1992; (355):446-449
Choi M, Moschetta A, Bookout AL, Peng L, Umetani M, Holmstrom SR, Suino-Powell K, Xu HE, Richardson JA, Gerard RD, Mangelsdorf DJ, Kliewer SA. , Nat Med , November 2006; (12):1253-5
Inagaki T., Choi M., Moschetta A., Peng L., Cummins C.L., McDonald J.G., Luo G., Jones S.A., Goodwin B., Richardson J.A., Gerard R.D., Repa J.J., Mangelsdorf D.J., Kliewer S.A. , Cell Metab , November 2005; (2):217-225
Inagaki T., Moschetta A., Lee Y-K, Peng L., Zhao G., Downes M., Yu R.T., Shelton J.M., Richardson J.A., Repa J.J., Mangelsdorf D.J., Kliewer S.A. , Proc Natl Acad USA , March 2006; (103):3920-5
Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA , Cell Metab , June 2007; (5):415-25
Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, Eliseenkova AV, Mohammadi M, Rosenblatt KP, Kliewer SA, Kuro-o M , J. Biol. Chem. , July 2007; ([epub ahead of print])
Honors/Awards
(2005)
(2004)
(2003)
(2002)