Michelle Seidel, PhD

Associate Professor
Molecular Biology
Graduate Program: Genetics and Development

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-5180
Office Fax: 214-648-1488

michelle.tallquist@utsouthwestern.edu

Biography

Michelle Tallquist received a BA in Chemistry from Kalamazoo College in 1989. After receiving her degree, she worked several years as an analytical chemist at The Upjohn Company. In 1992 she entered graduate school at the Mayo Clinic, where she studied immunology. For her thesis work she investigated the molecular basis of graft rejection. Her post-doctoral work was carried out in Seattle at the Fred Hutchinson Cancer Research Center where she used the power of mouse molecular genetics to unravel Platelet Derived Growth Factor signaling in vivo. Currently, she is an assistant professor at University of Texas Southwestern Medical Center at Dallas. She continues to study receptor tyrosine kinase signaling and has received several junior investigator awards including: the Scientist Development Award from the American Heart Association and the Basil O’Connor Starter Scholar Research Award from the March of Dimes.

Education

Graduate SchoolMayo Medical School, Biomedical Studies (1996)

Research Interests

Cancer biology
Cardiovascular development
Developmental biology
Mouse genetics
Signal transduction

Publications

Featured
White fat progenitor cells reside in the adipose vasculature

Tang W, Zeve D, Suh J, Bosnakovski D, Kyba M, Hammer B, Tallquist MD, Graff JM. , Science , September 2008; (Epub of print Sept 18)

Featured
Additive effects of PDGFRb signaling pathways in vascular smooth muscle cell development.

Tallquist, MD, French WJ, Soriano P. , PLoS , November 2003; (1(2)):E52

Featured
Disruption of PDGFRa-initiated PI3K activation and migration of somite derivatives leads to spina bifida

Pickett EA, Olsen GS, Tallquist MD. , Development , February 2008; (3/135):589-98

Featured
Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3’-kinase and phospholipase Cgamma signaling pathways.

Tallquist MD, Klinghoffer RA, Heuchel R, Mueting-Nelsen PF, Corrin PD, Heldin CH, Johnson RJ, Soriano P. , Genes and Development. , 2000; (14(24)):3179-90

PDGF receptors direct vascular development independent of vascular smooth

Wendy J. French, Esther E. Creemers, and Michelle D. Tallquist , Mol. Cell. Biol. , July 2008; (10.1128/MCB.00441-08)

Disruption of PDGFR{alpha}-initiated PI3K activation and migration of somite derivatives leads to spina bifida.

Pickett EA, Olsen GS, Tallquist MD. , Development , February 2008; (3/135):589-98

Cell autonomous requirement for PDGFRa in cranial and cardiac neural crest cells.

Tallquist, MD, Soriano, P , Development , February 2003; (130):507-518

PDGF receptor beta signaling is requiered for efficicent epicardial cell migration and development of two distinct corronary vascular smooth muscle cel populations

Mellgren AM, Smith CL, Olsen GS, Eskiocak B, Zhou B, Kazi MN, Ruiz FR, Pu WT, Tallquist MD. , Circulation Research , December 2008; (103 (12)):1393-401

Cooperation between the PDGF receptors in cardiac neural crest cell migration

Richarte AM, Mead HB, Tallquist MD. , Developmental Biology , April 2007; (306(2)):785-96

Honors/Awards

American Cancer Society Research Scholar

(2003)

Basil OConnor Grant

(2003)

AHA Scientist Development Grant

(2002)

Professional Associations/Affiliations

American Society of Microbiology

North American Vascular Biology Organization

Society for Developmental Biology