Michael Rosen, PhD

Professor
Endowed Title: Mar Nell and F. Andrew Bell Distinguished Chair in Biochemistry
Biochemistry, Pharmacology
Graduate Program: Biological Chemistry
Molecular Biophysics

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3338
Office Fax: 214-648-8856

michael.rosen@utsouthwestern.edu

Education

Graduate SchoolHarvard University (1993)

Research Interests

biochemistry
cell biology of the actin cytoskeleton
NMR spectroscopy
protein allostery and engineering
structural biology

Publications

Featured
Structure and control of the actin regulatory WAVE complex.

Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK, Nature, 2010 Nov; 468 (7323):533-8

Featured
Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

Yu, B., Martins, I. R. S., Li, P., Amarasinghe, G. K., Umetani, J., Fernandez-Zapico, M., Billadeau, D. D., Machius, M., Tomchick, D. R., Rosen, M. K. , Cell , 2010; (140):246-256

Featured
Hierarchical Regulation of WASP/WAVE Proteins

Padrick, S. B., Cheng, H.-C. C., Ismail, A., Panchal, S. C., Doolittle, L. K., Kim, S., Skehan, B.M., Umetani, J., Brautigam, C. A., Leong, J. M., Rosen, M. K. , Mol. Cell , 2008; (32):426-438

Genetically Encoded Photoswitching of Actin Assembly Through the Cdc42-WASP-Arp2/3 Complex Pathway

Leung, D. L., Otomo, C., Chory, J., Rosen, M. K. , Proc. Natl. Acad. Sci. , September 2008; (105(35)):12797-12802

Internal Dynamics Control Activation and Activity of the Autoinhibited Vav DH Domain

Li, P., Martins, I. R. S., Amarasinghe, G. K. and Rosen, M. K. , Nature Structural and Molecular Biology , May 2008; (15(6)):613-618

Structural Mechanism of WASP Activation by the Enterohaemorrhagic E. Coli Effector EspFu

Cheng, H.-C., Skehan, B. M., Leong, J. M., Rosen, M. K. , Nature , May 2008; (454):1009-1013

Mechanism of actin filament nucleation by the bacterial effector VopL.

Yu B, Cheng HC, Brautigam CA, Tomchick DR, Rosen MK, Nature structural & molecular biology, 2011 Sep; 18 (9)

Arp2/3 complex is bound and activated by two WASP proteins.

Padrick SB, Doolittle LK, Brautigam CA, King DS, Rosen MK, Proceedings of the National Academy of Sciences of the United States of America, 2011 Jun; :E472-9

Arp2/3 complex is bound and activated by two WASP proteins.

Padrick SB, Doolittle LK, Brautigam CA, King DS, Rosen MK, Proceedings of the National Academy of Sciences of the United States of America, 2011 Jun; :E472-9

Physical mechanisms of signal integration by WASP family proteins.

Padrick SB, Rosen MK, Annual review of biochemistry, 2010 ; 79:707-35

Honors/Awards

Edith & Peter O’Donnell Award from the Texas Academy of Medicine, Engineering and Science

(2006)

Howard Hughes Medical Institute

(2005)

Boyer Award, Memorial Sloan-Kettering Cancer Center

(2001)

Howard Hughes Medical Institute

(2000)

Beckman Young Investigator

(1997)