Kim Orth, PhD

Professor
Endowed Title: W.W. Caruth, Jr. Scholar in Medical Research 2002-2006
Molecular Biology, Biochemistry
Graduate Program: Biological Chemistry
Genetics and Development

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-1685
Office Fax: 214-648-1488

kim.orth@utsouthwestern.edu

Education

Graduate SchoolUniversity of Texas Southwestern Med Ctr Dallas (1993)
Graduate SchoolUniversity of California-Los Angeles (1986)
UndergraduateTexas A & M University (1984)

Research Interests

Biochemistry
Cellular Signaling
Molecular Microbiology

Publications

Featured
A Vibrio Effector Protein is an Inositol Phosphatase and Disrupts Host Cell Membrane Integrity

Broberg, C. A., Zhang, L.L., Gonzalez, H., Laskowski-Arce, M.A. & Orth, K , Science , September 2010; (329):1660-1662

Featured
AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling.

Yarbrough, M., Li, Y., Kinch, L.N., Grishin, N.V., Hall B.E., & Orth, K. , Science , January 2009; (323):269-272

Featured
Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways

Yi-Heng Hao,, Yong Wang, Dara Burdette, Sohini Mukherjee, Gladys Keitany, Elizabeth Goldsmith & Kim Orth , PLoS ONE , January 2008; (3(1)):e1375

Featured
Vibrio parahaemolyticus orchestrates a multifaceted host cell infection by induction of autophagy, cell rounding and then cell lyses.

Burdette, D., Yarbrough, M., Orvedahl, A., Gilpin, C. & Orth, K. , PNAS USA , 2008; (105):12497-12502

Featured
Arp2/3 Independent Assembly of Actin by Vibrio Type III Effector VopL

Amy D.B. Liverman, Hui-Chun Cheng, Jennifer E. Trosky, Daisy W. Leung, Melanie L. Yarbrough, Dara L. Burdette, Michael K. Rosen and Kim Orth , PNAS (USA) , October 2007; (104:43):17117-17122

Featured
Yersinia YopJ Acetylates and Inhibits Kinase Activation by Preventing Phosphorylation

Mukherjee, S. Kietany, G., Li, Y Wang, Y., Hall B.E., Goldsmith, E & Orth, K , Science , 2006; (312):1211-1214

A Vibrio Effector Protein is an Inositol Phosphatase and Disrupts Host Cell Membrane Integrity

Broberg, C. A., Zhang, L.L., Gonzalez, H., Laskowski-Arce, M.A. & Orth, K , Science , September 2010; (329):1660-1662

Vibrio VopQ Induces PI3-Kinase Independent Autophagy and Antagonizes Phagocytosis.

Burdette, D., Seemann, J. & Orth, K , Molecular Microbiology , August 2009; (73):639-649

AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling.

Yarbrough, M., Li, Y., Kinch, L.N., Grishin, N.V., Hall B.E., & Orth, K. , Science , January 2009; (323):269-272

VopS Fic Domain uses direct transfer mechanism for AMPylation.

Luong, P., Kinch, L.N., Brautigam, C.A., Grishin, N.V., Tomchick, D.R. & Orth, K , Journal of Biological Chemistry , June 2010; (285(26)):20155-20163

Honors/Awards

TAMEST; 2011 Edith & Peter O?Donnell Award in Science

(2011)

The Welch Foundation Norman Hackerman Award in Chemical Research

(2010)

Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease

(2006)

Arnold and Mabel Beckman Young Investigator Award

(2003)

W. W. Caruth, Jr. Scholar in Biomedical Research

(2001)