Jeffrey Browning, M.D.

The focus of my research is the comprehensive study of non-alcoholic fatty liver disease (NAFLD) in humans. The overarching goal is to understand the metabolic derangements that lead to this disease through the application of advanced imaging and metabolic techniques. Translating these basic science techniques to the clinical realm allows for a more complete understanding of the pathophysiology of NAFLD and extension of this understanding through complimentary studies utilizing traditional clinical research tools (epidemiology, retrospective and prospective studies, and clinical trials). In addition to the knowledge gained, this approach allows for the development of novel therapeutic and diagnostic modalities in a logical, disease- and patient-oriented manner.

My initial interest in metabolism began during medical school when I participated in nuclear magnetic resonance (NMR) studies using a variety of stable isotope tracers to investigate glycolysis in rats. As a result of my initial work, I have returned to the group at the Advanced Imaging Research Center (AIRC), becoming proficient in the application of high-field NMR spectroscopy and stable isotopes to track metabolic pathways in humans. The primary goal of my research is to create an integrated approach to the study of hepatic glucose and lipid metabolism that allows for multiple simultaneous metabolic flux measurements to be made. We have already applied these techniques in rodents as well as humans (with and without NAFLD) under a variety of conditions.

It is my view that disease-oriented research should be comprehensive in nature, exploiting available basic science modalities to enhance our understanding of the pathophysiology of a disease while simultaneously translating this new-found knowledge into the clinical realm. This allows for a focused and logical approach to the study of a disease, an approach that has a high likelihood of impacting clinical practice and improving patient care.

Medical School

UT Southwestern Medical School (1998)

Internship

University of Alabama Medical Center at Birmingham (1999), Internal Medicine

Residency

University of Alabama Medical Center at Birmingham (2001), Internal Medicine

Fellowship

UT Southwestern Medical Center (2004), Gastroenterology

Featured Publications

Dallas Steatosis Index Identifies Patients With Nonalcoholic Fatty Liver Disease.

McHenry S, Park Y, Browning JD, Sayuk G, Davidson NO, Clin. Gastroenterol. Hepatol. 2020 Jan

Simultaneous tracers and a unified model of positional and mass isotopomers for quantification of metabolic flux in liver.

Deja S, Fu X, Fletcher JA, Kucejova B, Browning JD, Young JD, Burgess SC, Metab. Eng. 2019 Dec

Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver.

Fletcher JA, Deja S, Satapati S, Fu X, Burgess SC, Browning JD, JCI Insight 2019 Apr 5

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver.

Cappel DA, Deja S, Duarte JAG, Kucejova B, Iñigo M, Fletcher JA, Fu X, Berglund ED, Liu T, Elmquist JK, Hammer S, Mishra P, Browning JD, Burgess SC, Cell Metab. 2019 Apr

Crohn's Disease Is Associated With an Increased Prevalence of Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study Using Magnetic Resonance Proton Density Fat Fraction Mapping.

Mchenry S, Sharma Y, Tirath A, Tsai R, Mintz A, Fraum TJ, Salter A, Browning JD, Flores AG, Davidson NO, Fowler KJ, Ciorba MA, Deepa P, Clin. Gastroenterol. Hepatol. 2019 Mar

Fatty Liver Disrupts Glycerol Metabolism in Gluconeogenic and Lipogenic Pathways in Humans.

Jin ES, Browning JD, Murphy RE, Malloy CR J. Lipid Res. 2018 Jul

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.

Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston K, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC J. Clin. Invest. 2015 Dec 125 12 4447-4462

Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic Fatty liver disease.

Lambert JE, Ramos-Roman MA, Browning JD, Parks EJ Gastroenterology 2014 Mar 146 3 726-35

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver.

Satapati S, Sunny NE, Kucejova B, Fu X, He TT, Méndez-Lucas A, Shelton JM, Perales JC, Browning JD, Burgess SC J. Lipid Res. 2012 Jun 53 6 1080-92

Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease.

Sunny NE, Parks EJ, Browning JD, Burgess SC Cell Metab. 2011 Dec 14 6 804-10

 Featured Books

Gallstone Disease. In Sleisinger & Fordtran's Gastrointestinal and Liver Disease, 8th edition

Browning JD, Sreenarasimhaiah J (2006). Philadelphia, Saunders

• Margo A. Denke, M.D. Professorship in Clinical Nutrition Research
  University of Texas Southwestern Medical School, Dallas, TX (2017)
• Disease Oriented Clinical Scholar (DOCS)
  University of Texas Southwestern Medical School, Dallas, TX (2006)
• Diplomate
  American Board of Internal Medicine, Gastroenterology (2005)
• Research Excellence in GI and Liver (REGAL) Award
  University of Kansas Medical Center / Janssen Pharmaceutica / Centocor / Ortho-Biotech Products (2005)
• NIH Training Fellowship
  NIH (2003)
• Postdoctoral Fellowship
  American Liver Foundation (2003)
• Diplomate
  American Board of Internal Medicine (2001)
• Ben Friedman Award for excellence in teaching
  University of Alabama, Birmingham, Birmingham, AL (2001)
• Ben Friedman Award for excellence in teaching
  University of Alabama, Birmingham, Birmingham, AL (1998)

• Medical Director (2010)