Craig Powell, MD, PhD

Associate Professor
Neurology and Neurotherapeutics, Psychiatry
Graduate Program: Neuroscience

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

craig.powell@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Biography

Dr. Craig M. Powell earned both his M.D. with honor and Ph.D. in Neuroscience research at Baylor College of Medicine in 1994 and 1997 respectively. His graduate work with Drs. David Sweatt and Dan Johnston was among the first studies to measure lasting biochemical changes during long-lasting synaptic plasticity in the hippocampus. After his Medical Internship year at Baylor College of Medicine, Dr. Powell trained at the University of California, San Francisco Neurology Residency Program. In his final year, Dr. Powell was chosen to be the Chief Resident in the UCSF Neurology Program. Dr. Powell was elected to Phi Beta Kappa as an undergraduate as well as to Alpha Omega Alpha medical Honor society in medical school.

Currently, Dr. Powell is a tenured Associate Professor at The University of Texas Southwestern Medical Center's Depts. of Neurology & Neurotherapeutics and Psychiatry and an active member of the Neuroscience Graduate Program. His basic laboratory research is focused on the molecular mechanisms of learning and memory, synaptic plasticity, and neuropsychiatric disorders such as autism, mental retardation, and Alzheimer’s. Dr. Powell's clinical Neurology practice is on the inpatient Neurology services at the University Hospitals and Parkland Memorial Hospital. Dr. Powell also supervises and teaches Neurology Residents as they see patients at the Parkland Memorial Hospital outpatient clinics.

Education

ResidencyUniversity of California at San Francisco, Neurology (2001)
InternshipBaylor College of Medicine, Transitional Year (1998)
Medical SchoolBaylor College of Medicine (1997)
Graduate SchoolBaylor College of Medicine, Neuroscience (1994)

Research Interests

Alzheiemer's Disease: Translational Research for Prevention and Treatment
Autism: Mechanisms and Future Treatment
Mental Retardation Syndromes
Molecular Basis of Neuropsychiatric Disease
Molecular Mechanisms of Learning, Memory, & Synaptic Plasticity

Publications

Featured
A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice.

Tabuchi, K., Blundell, J., Etherton, M.R., Hammer, R.E., Liu, X., Powell, C.M., & Sudhof, T.C. , Science , October 2007; (318):71-76

Featured
Block of glucocorticoid synthesis during re-activation inhibits extinction of an established fear memory.

Blundell J, Blaiss CA, Lagace DC, Eisch AJ, Powell CM, Neurobiology of learning and memory, 2011 May; 95 (4):453-60

Featured
Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism.

Bangash MA, Park JM, Melnikova T, Wang D, Jeon SK, Lee D, Syeda S, Kim J, Kouser M, Schwartz J, Cui Y, Zhao X, Speed HE, Kee SE, Tu JC, Hu JH, Petralia RS, Linden DJ, Powell CM, Savonenko A, Xiao B, Worley PF, Cell, 2011 May; 145 (5):758-72

Featured
Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury.

Blaiss CA, Yu TS, Zhang G, Chen J, Dimchev G, Parada LF, Powell CM, Kernie SG, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011 Mar; 31 (13):4906-16

Featured
Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior.

Blundell J, Blaiss CA, Etherton MR, Espinosa F, Tabuchi K, Walz C, Bolliger MF, Südhof TC, Powell CM, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010 Feb; 30 (6):2115-29

Featured
RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia.

Blundell J, Kaeser PS, Südhof TC, Powell CM, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010 Apr; 30 (15):5326-33

Featured
Neuroligin 1 Deletion Results in Impaired Spatial Memory and Increased Repetitive Behavior

Blundell, J., Blaiss, C.A., Etherton, M.R., Espinosa, F., Tabuchi, K., Walz, C., Bolliger, M.F., Sudhof, T.C., & Powell, C.M. , Journal of Neuroscience , 2010; (in press)

Featured
Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments.

Etherton MR, Blaiss CA, Powell CM, Südhof TC, Proceedings of the National Academy of Sciences of the United States of America, 2009 Oct; 106 (42):17998-8003

Featured
Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice.

Zhou J, Blundell J, Ogawa S, Kwon CH, Zhang W, Sinton C, Powell CM, Parada LF, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009 Feb; 29 (6):1773-83

Featured
Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2.

Blundell J, Tabuchi K, Bolliger MF, Blaiss CA, Brose N, Liu X, Südhof TC, Powell CM, Genes, brain, and behavior, 2009 Feb; 8 (1):114-26

Honors/Awards

Elected Member ANA

(2010)

Elected Associate Member ACNP

(2009)

ACNP Young Investigator Travel Award

(2007)

Autism Young Investigator Award--Neurobiology of Autism and Related Disorders

(2007)

NARSAD Young Investigator Award

National Alliance for Research on Schizophrenia and Depression basic research grant (2003)

NIMH K08 Award

National Institute of Mental Health basic research grant (2003)

Neurology Chief Resident--UCSF

(2000)

Alpha Omega Alpha

(1997)

Professional Associations/Affiliations

American College of Neuropsychopharmacology

American Neurological Association (ANA), American Academy of Neurology (AAN)

International Society for Autism Research

Molecular and Cellular Cognition Society

Society for Neuroscience