Qinghua Liu, PhD

Associate Professor
Endowed Title: W.A. "Tex" Moncrief Jr. Scholar in Medical Research 2004-2008
Biochemistry
Graduate Program: Biological Chemistry

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3338
Office Fax: 214-648-8856

qinghua.liu@utsouthwestern.edu

Education

Graduate SchoolBaylor College of Medicine, Cell Biology (2001)
UndergraduateWuhan University - China, Biochemistry (1992)

Research Interests

Biochemical mechanism of RNA interference
Drosophila germline stem cells
MicroRNA-mediated translational repression
Regulation of RNA interference

Publications

Featured
The miRNA pathway intrinsically controls self-renewal of Drosophila germline stem cells.

J. Park, X. Liu, T. Strauss, F. Jiang, Y. Liu, D. McKearin, and Q. Liu , Curr. Biol. , 2007; (17):533?538

Featured
Dicer-1 and R3D1-L catalyze miRNA maturation in Drosophila

F. Jiang, X. Ye, X. Liu, L. Fincher, D. McKearin, Q. Liu , Genes Dev. , 2005; (19):1674-1679

Featured
R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway.

Q. Liu, T. A. Rand, S. Kalidas, F. Du, H. Kim, D.P. Smith, X. Wang , Science , 2003; (301):1921-1925

Featured
Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint.

Q. Liu, S. Guntuku, X. Cui, S. Matsuoka, D. Cortez, K. Tamai, G. Luo, S. Carattini-Rivera, F. Demayo, A. Bradley, L.A. Donehower, and S.J. Elledge , Genes Dev. , 2000; (14):1448-1459

Featured
The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes.

Q. Liu, M. Z. Li, D. Liebham, D. Cortez, S. J. Elledge , Curr. Biol. , 1998; (8):1300-1309

Phosphorylation of the human micro-RNA generating complex mediates MAPK/Erk signaling

Z. Paroo, X. Ye, S. Chen, and Q. Liu , Cell , October 2009; (139):112-122

The functional anatomy of Drosophiila microRNA-generating enzyme

X. Ye, P. Zain, and Q. Liu , J. Biol. Chem. , July 2007; (282 (39)):28373-28378

C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation

Y. Liu, X. Ye, F. Jiang, C. Liang, D. Chen, P. Jun, L.N. Kinch, N.V. Grishin, Q. Liu , Science , August 2009; (325):750-753

The miRNA pathway intrinsically controls self-renewal of Drosophila germline stem cells.

J. Park*, X. Liu*, T. Strauss, D. McKearin, and Q. Liu , Curr. Biol. , 2007; (17):533-538

Dicer-1 and R3D1-L catalyze miRNA maturation in Drosophila.

F. Jiang, X. Ye, X. Liu, L. Fincher, D. McKearin, Q. Liu , Genes Dev. , 2005; (19):1674-1679

Honors/Awards

Damon Runyon Scholar Award

(2005)

Deborah and W.A. "Tex" Moncrief, Jr. Scholar in Medical Research

(2004)