David Self, PhD

Professor
Endowed Title: Wesley Gilliland Professorship in Biomedical Research
Psychiatry
Graduate Program: Neuroscience

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-1237
Office Fax: 214-648-4947

david.self@utsouthwestern.edu

Biography

Dr. Self received his bachelor’s in Zoology from Iowa State University in 1985, and worked as a biochemist at Endocrine Sciences in Los Angeles, CA until 1987. Dr. Self entered graduate school in 1987 in the Department of Pharmacology at UC Irvine, and received a PhD there in 1992. Dr. Self was a postdoctoral fellow from 1992-1995 in the Division of Molecular Psychiatry at Yale University. Dr. Self was appointed to an Assistant Professorship in the Psychiatry Department at Yale University in 1996.

In late 2000, Dr. Self joined the UT Southwestern faculty as an Associate Professor of Psychiatry in the Seay Center for Basic and Applied Research in Psychiatric Illness. Dr. Self has pioneered work on the role of neuroadaptations in addictive behavior, and has identified important neurobiological mechanisms underlying drug craving and relapse to drug seeking. In 1996, he was awarded a Presidential Early Career Award by the White House, and in 2007, the prestigious Daniel H. Efron Award by the American College of Neuropsychopharmacology, for contributions relating to this work. His laboratory continues to implement modern molecular technology in the study of addictive behavior.

Education

Graduate SchoolUniversity of California-Irvine (1992)
UndergraduateIowa State University (1985)

Research Interests

Behavioral Neuroscience
Neurobiology of Addiction
Neuropharmacology
Systems Neuroscience

Publications

Featured
Molecular and genetic approaches for behavioral analysis of protein function

Self, D.W. , Biological Psychiatry , 2005; (57):1479-1484

Featured
Extinction training regulates neuroadaptive responses to withdrawal from chronic cocaine self-administration.

Self, D.W. Choi, K-H., Simmons, D., Walker, J.R. and Smagula, C.S. , Learning and Memory , 2004; (11):648-657

Featured
Striatal cell type-specific overexpression of ?FosB enhances incentive for cocaine.

Colby, C.R., Whisler, K., Steffen, C., Nestler, E.J., Self, D.W. , J. Neurosci. , 2003; (23):2488-2493

Featured
Extinction-induced up-regulation in AMPA receptors reduces cocaine-seeking behavior.

Sutton, M.A., Schmidt, E.F., Choi, K-H., Schad, C.A., Whisler, K., Simmons, D., Karanian, D.A., Monteggia, L.M., Neve, R.L. and Self, D.W. , Nature , 2003; (421):70-75

Featured
Opposite modulation of cocaine-seeking behavior by D1- and D2-like dopamine receptor agonists.

Self, D.W., Barnhart, W.J., Lehman, D.A. and Nestler, E.J. , Science , 1996; (271):1586-1589

Tropomyosin-related kinase B in the mesolimbic dopamine: Region-specific effects on cocaine reward.

Graham, D.L., Krishnan, V., Larson, E.B., Graham, A., Edwards, S., Bachtell, R.K., Simmons, D., Gent, L.M., Berton, O., Bolanos, C.A., DiLeone, R.J., Parada, L.F., Nestler, E.J. and Self, D.W. , Biological Psychiatry , 2009; (65):896-901

Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behavior.

Bachtell, R.K., Choi, K-H., Monteggia, L.M., Neve, R. L. and Self, D.W. , European Journal of Neuroscience , 2008; (27):2229-2240

Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse.

Graham, D.L., Edwards, S., Bachtell, R.K., DiLeone, R.J, Rios, M. and Self, D.W. , Nature Neuroscience , 2007; (10):1029-1037

Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration.

Edwards, S., Whisler, K.N., Fuller. D.C., Orsulak, P.J. and Self, D.W. , Neuropsychopharmacology , 2007; (32):354-366

Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration.

Edwards, S., Graham, D.L., Bachtell, R.K. and Self, D.W. , Eur. J. Neurosci , 2007; (25):2201-2213

Honors/Awards

Daniel H. Efron Research Award

American College of Neuropsychopharmacology (2006)

Elected to full membership

American College of Neuropsychopharmacology (2003)

Lydia Bryant Test Professorship

Dept. of Psychiatry. UT Southwestern Medical Center (2001)

Presidential Early Career Award for Scientists and Engineers (PECASE)

Awarded by the White House for "Innovative integration of molecular biology with behavioral, pharmacological and biochemical techniques in the study of drug addiction" (1996)

Professional Associations/Affiliations

American College of Neuropsychopharmacology

College on Problems of Drug Dependence

European Behavioural Pharmacology Society

Society for Neuroscience

Society of Biological Psychiatry