Lisa Monteggia, PhD

Associate Professor
Endowed Title: Ginny and John Eulich Professorship in Autism Spectrum Disorders
Psychiatry
Graduate Program: Integrative Biology
Neuroscience

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-5548
Office Fax: 214-648-4182

lisa.monteggia@utsouthwestern.edu

Biography

Dr. Monteggia received her undergraduate degree in Microbiology at the University of Illinois at Urbana-Champaign in 1989. She then went on to obtain her master’s degree in Biology at the University of Illinois at Urbana-Champaign in 1991.

Dr. Monteggia worked several years in the pharmaceutical industry, concurrently working on her PhD in Neuroscience at Chicago Medical School which was awarded in 1998 under the direction of Marina Wolf. Dr. Monteggia was a post-doctoral fellow at Yale University in the Laboratory of Molecular Psychiatry under the direction of Eric Nestler, M.D., PhD. She joined UT Southwestern in October of 2002 as an Assistant Professor and is interested in the molecular and cellular basis of neural plasticity as it pertains to neuropsychiatric disorders.

Education

Graduate SchoolUniversity of Illinois Urbana Campus (1991)
UndergraduateUniversity of Illinois Urbana Campus (1989)

Research Interests

Development of Animal Models for Psychiatric Diseases
Elucidating the Role of MeCP2 in Mediating Autistic-like Behavior (autism)
Role of Growth Factors in Depression
Role of Transcriptional Repression in Neurons

Publications

Featured
Activity-dependent suppression of miniatureneurotransmission through the regulation of DNA methylation

Nelson ED, Kavalali ET, Monteggia LM , J Neurosci , 2008; (28(2):):395-406

Featured
MeCP2-dependent transcriptional repression regulates excitatory neurotransmission

Nelson E, Kavalali ET, Monteggia LM , Current Biology , 2006; (16):710-716

Featured
Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress

Berton, O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ , Science , 2006; (311):864-868

Featured
Essential Role of BDNF in Adult Hippocampal Function and Depression

Monteggia LM, Barrot M, Powell C, Berton O, Galanis V, Nagy A, Greene RW, Nestler EJ , Proc Natl Acad Sci , 2004; (101(29)):10827-10832

Featured
Neurobiology of Depression

Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM , Neuron , 2002; (34(1)):13-25

BDNF Conditional Knockouts Show Gender Differences in Depression Related Behaviors.

Monteggia LM, Luikart B, Barrot M, Nef S, Parada LF, Nestler EJ , Biological Psychiatry , 2007; (61(2)):187-197

Regulation of 5-HT1A receptor function in inducible BDNF knock-out mice following administration of corticosterone.

Hensler JG, Advani T, Monteggia LM , Biological Psychiatry , 2007; (Epub March 2)

Long Term Behavioral and Molecular Alterations Associated with Maternal Separation in Rats.

Lippmann M, Bress A, Nemeroff CB, Plotsky PM, Monteggia LM , European Journal of Neuroscience , 2007; (25(10)):3091-3098

Reciprocal interaction of activity and 5-HT in regulation of CRE-dependent gene expression.

Mahgoub MA, Sara Y, Kavalali ET, Monteggia LM , J Pharmacol Exp Ther , 2006; (317(1)):88-96

Postnatal loss of MeCP2 in the forebrain is sufficient to mediate behavioral aspects of Rett Syndrome in mice

Gemelli T, Berton O, Nelson E, Perroti LI, Jaenisch R, Monteggia LM , Biol Psychiatry , 2005; (Epub Sept 28)

Honors/Awards

Rising Star Award

International Mental Health Research Organization (2011)

Ginny and John Eulich Professorship in Autism Spectrum Disorders

(2010)

Daniel X. Freedman Award

Award for Outstanding Basic Research Achievement, (NARSAD) (2005)

2003, 2001 Young Investigator Awards

National Alliance for Research on Schizophrenia and Depression (NARSAD) (2003)

Independent Investigator Award

National Alliance for Autism Research (NAAR) (2001)

Professional Associations/Affiliations

American College of Neuropharmacology

Serotonin Club

Society for Neuroscience