Dominika Borek, PhD

Assistant Professor
Biochemistry
Graduate Program: Molecular Biophysics

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3338
Office Fax: 214-648-8856

dominika.borek@utsouthwestern.edu

Education

Graduate SchoolAdam Mickiewicz University, Poznan, Polland (2001)

Research Interests

chromatin structure
evolution
next generation sequencing
statistical methods in protein crystallography
structural biology

Publications

Featured
Diffraction data analysis in the presence of radiation damage.

Borek D, Cymborowski M, Machius M, Minor W, Otwinowski Z, Acta crystallographica. Section D, Biological crystallography, 2010 Apr; 66 (Pt 4):426-36

Featured
The many faces of radiation-induced changes.

Borek D, Ginell SL, Cymborowski M, Minor W, Otwinowski Z, Journal of synchrotron radiation, 2007 Jan; 14 (Pt 1):24-33

Featured
Expression, purification and catalytic activity of Lupinus luteus asparagine beta-amidohydrolase and its Escherichia coli homolog.

Borek D, Michalska K, Brzezinski K, Kisiel A, Podkowinski J, Bonthron DT, Krowarsch D, Otlewski J, Jaskolski M, European journal of biochemistry / FEBS, 2004 Aug; 271 (15):3215-26

Featured
Measurement errors and their consequences in protein crystallography.

Borek D, Minor W, Otwinowski Z, Acta crystallographica. Section D, Biological crystallography, 2003 Nov; 59 (Pt 11):2031-8

Featured
Multiparametric scaling of diffraction intensities.

Otwinowski Z, Borek D, Majewski W, Minor W, Acta crystallographica. Section A, Foundations of crystallography, 2003 May; 59 (Pt 3):228-34

Crystal Structure of Cardiac Troponin C Regulatory Domain in Complex with Cadmium and Deoxycholic Acid Reveals Novel Conformation.

Li AY, Lee J, Borek D, Otwinowski Z, Tibbits GF, Paetzel M, Journal of molecular biology, 2011 Sep;

To automate or not to automate: this is the question.

Cymborowski M, Klimecka M, Chruszcz M, Zimmerman MD, Shumilin IA, Borek D, Lazarski K, Joachimiak A, Otwinowski Z, Anderson W, Minor W, Journal of structural and functional genomics, 2010 Sep; 11 (3):211-21

Structure and control of the actin regulatory WAVE complex.

Chen Z, Borek D, Padrick SB, Gomez TS, Metlagel Z, Ismail AM, Umetani J, Billadeau DD, Otwinowski Z, Rosen MK, Nature, 2010 Nov; 468 (7323):533-8

Structural and functional characterization of Reston Ebola virus VP35 interferon inhibitory domain.

Leung DW, Shabman RS, Farahbakhsh M, Prins KC, Borek DM, Wang T, Mühlberger E, Basler CF, Amarasinghe GK, Journal of molecular biology, 2010 Jun; 399 (3):347-57

Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins.

Leung DW, Borek D, Farahbakhsh M, Ramanan P, Nix JC, Wang T, Prins KC, Otwinowski Z, Honzatko RB, Helgeson LA, Basler CF, Amarasinghe GK, Acta crystallographica. Section F, Structural biology and crystallization communications, 2010 Jun; 66 (Pt 6):689-92

Honors/Awards

NARSAD Young Investigator Award

(2005)

Professional Associations/Affiliations

American Crystallographic Association

American Society for Cell Biology