Andreas Reimold, MD

Assistant Professor
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

andreas.reimold@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Biography

The focus of the Reimold lab's research program is to understand how transcription factors control the expression of genes involved in inflammation. Insights into how these proteins turn genes on and off may lead to new treatments for rheumatic diseases. They have studied transcription factors binding to DNA at cyclic AMP response elements, a sequence of widespread importance in the regulation of proinflammatory genes. To determine the precise functions of these transcription factors, mice with targeted disruptions of the genes under study were genereated and have revealed defects in embryonic growth and development, as well as impaired activation of inflammatory pathways. Recently they have identified a block in the pathway of B lymphocyte terminal differentiation in one of our knockout mouse models. Further work will help to elucidate how the interaction of transcription factors with each other and with their target genes regulates the production of immunoglobulin-secreting plasma cells.

Education

FellowshipHarvard Medical School, Immunology (1993)
FellowshipHarvard Medical School, Rheumatology (1991)
Medical SchoolColumbia University College of Physicians and Surgeons (1984)

Research Interests

Mechanisms of B cell differentiation
Transcriptional regulation of lymphocyte function

Publications

New indications for treatment of chronic inflammation by TNFa blockade

Reimold, A.M. , American Journal of Medical Science , 2003; (325):75-92

Plasma cell differentiation requires the trasncription factor XBP-1

Reimold A.M., N.N. Iwakoshi, J. Manis, P. Vallabhajosyula, E. Szomolanyi-Tsuda, E.M. Gravallese, D. Friend, M.J. Grusby, F. Alt, L.H. Glimcher , Nature , 2001; (412):300-307

An essential role in liver development for transcription factor XBP-1

Reimold A.M., A. Etkin, I Clauss, A. Perkins, D.S. Friend, J. Zhang, H.F. Horton, A. Scott, S. Orkin, M.C. Byrne, M.J. Grusby, L.H. Glimcher , Genes and Development , 2000; (14):152-157

Honors/Awards

Lyndon Baines Johnson Research Award

American Heart Association (2002)

Arthritis Investigator Award

American College of Rheumatology (1997)

Professional Associations/Affiliations

American Association of Immunologists

American College of Rheumatology

Arthritis Foundation