Francesca DiSole, PhD

Assistant Professor
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

francesca.disole@utsouthwestern.edu

Education

Graduate SchoolUniversity of Bari - Italy, Physiology (1999)
Graduate SchoolUniversity of Bari - Italy, Biology (1994)

Research Interests

Cellular and Molecular Physiology of the Kidney
Ion Transport

Publications

Featured
The Calcineurin Homologous Protein-1 increases Na+/H+ -exchanger 3 trafficking via ezrin phosphorylation

F Di Sole, V Babich, and OW Moe , J Am Soc Nephrol , June 2009; (20):1776-86

Featured
Acute regulation of Na/H exchanger NHE3 by adenosine A(1) receptors is mediated by calcineurin homologous protein

F Di Sole, R Cerull, V Babich, H Quinones, SM Gisler, J Biber, H Murer, G Burckhardt, C Helmle-Kolb, OW Moe , J Biol Chem , January 2004; (279(4)):2962-74

Featured
Expression and role of serum and glucocorticoid regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in mammalian kidney.

AC Pao, A Bhargava, F Di Sole, R Quigley, X Shao, J Wang, S Thomas, J Zhang, M Shi, JW Funder, OW Moe , Am J Physiol Renal Physiol , December 2010; (299(6)):F1496-506

Featured
Acute regulation of renal Na+/H+ exchanger NHE3 by dopamine: role of protein phosphatase 2A

IA Bobulescu, H Quinones, SM Gisler, F Di Sole, MC Hu, M Shi, J Zhang, DG Fuster, N Wright, M Mumby, OW Moe , Am J Physiol Renal Physiol , 2010; (298(5)):F1205-F1213

Molecular aspects of acute inhibition of Na(+)-H(+) exchanger NHE3 by A(2)-adenosine receptor agonists

F Di Sole, R Cerull, S Petzke, V Casavola, OW Moe, G Burckhardt, C Helmle-Kolb , J Physiol , June 2002; (541(Pt 2)):529-43

Adenosine and renal tubular function

F Di Sole , Curr Opin Nephrol Hypertens , July 2008; (17(4)):399-407

Short- and long-term A3 adenosine receptor activation inhibits the Na+/H+ exchanger NHE3 activity and expression in opossum kidney cells.

F Di Sole, R Cerull, V Babich, V Casavola, C Helmle-Roth, G Burckhardt , J Cell Physiol , July 2008; (216(1)):221-33

Bimodal acute effects of A1 adenosine receptor activation on Na+/H+ exchanger NHE3 in opossum kidney cells

F Di Sole, R Cerull, S Petzke, V Casavola, G Burckhardt, C Helmle-Kolb , J Am Soc Nephrol , July 2003; (14(7)):1720-30

NHERF1 overexpression-dependent increase of cytoskeleton organization is fundamental in the rescue of F508del CFTR in human airway CFBE41o-cells.

M Favia, L Guerra, T Fanelli, RA Cardone, S Monterisi, F Di Sole, S Castellani, M Chen, U Seidler, SJ Reshkin, M Conese, and V Casavola , Mol Biol Cell , January 2010; (21(1)):73-86

Honors/Awards

American Society of Nephrology

Carl W. Gottschalk Research Scholar - Career Development Award (2009)

International Society of Nephrology

Travel Grant (2009)

Royal Society

Travel Grant (2005)

American Heart Association Texas

Postdoctoral Fellowship Award (2003)

International Society of Nephrology

Best Abstract Award (2003)

Professional Associations/Affiliations

American Physiological Society

American Society for Biochemistry and Molecular Biology

American Society for Cell Biology

American Society of Nephrology