Christoph Wuelfing, PhD

Associate Professor
Endowed Title: W.A. Moncrief Jr. Scholar in Medical Research 2000-2004
Immunology, Cell Biology
Graduate Program: Cell Regulation
Immunology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-7320
Office Fax: 214-648-7331

cwuelf@mednet.swmed.edu

Biography

10/89-3/94       Ph.D. thesis in the Protein Engineering Group at the Max-Planck-Institute of Biochemistry, Martinsried, Germany

7/94-12/99       Postdoctoral Fellow and Research Associate of the Howard Hughes Medical Institute at Stanford University, Stanford, CA, Dr. Mark M. Davis

Education

Graduate SchoolMax-Planck Institute of Biochemistry, Biochemistry (1994)

Research Interests

A more detailed description of our research interests can be found at www4.utsouthwestern.edu/wuelfinglab
Live cell imaging of lymphocyte signal transduction and polarization
The role of NK cell polarization in NK cell function
The spatiotemporal organization of T cell signaling as a regulator of T cell function

Publications

Featured
Spatiotemporal patterning during T cell activation is highly diverse

Singleton, K. L., Roybal, K. T., Sun, Y., Fu, G., Gascoigne, N. R. J., van Oers, N. S. C., and Wulfing, C. , Sci. Signal. , April 2009; (2):ra15

Featured
Itk controls the spatiotemporal organization of T cell activation.

Singleton KL, Gosh M, Dandekar RD, Au-Yeung BB, Ksionda O, Tybulewicz VL, Altman A, Fowell DJ, Wülfing C, Science signaling, 2011 Oct; 4 (193)

Featured
Transience in polarization of cytolytic effectors is required for efficient killing and controlled by Cdc42

Sinai, P., Nguyen, C., Schatzle, J. D., and Wulfing, C. , Proc. Natl. Acad. Sci. USA , 2010; 107:11912-7

Featured
T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells

Purtic, B., Pitcher, L. A., van Oers, N. S. C., and Wulfing, C. , Proc. Natl. Acad. Sci. USA , 2005; 102:2904-9

Featured
Stepwise cytoskeletal polarization as a series of checkpoints in innate but not adaptive cytolytic killing.

Wulfing, C., Klem, J., Purtic, B., and Schatzle, J. D. , Proc. Natl. Acad. Sci. USA , 2003; 100:7767

PIP2 controls T cell activation by regulating T cell rigidity and spatiotemporal organization.

Sun, Y., Dandekar, R. D., Mao, Y. S., Yin, H. L, Wülfing, C., PLoS ONE, 2011; 6:in press

Protein transduction as a means of effective manipulation of Cdc42 activity in primary T cells

Tskvitaria-Fuller, I., Mistry, N., Sun, S., and Wulfing, C. , J. immunol. Methods , 2007; 319:64-78

Specific Patterns of Cdc42 Activity Are Related to Distinct Elements of T cell Polarization

I. Tskvitaria-Fuller, A. Seth, N. Mistry, H. Gu, M.K. Rosen, and C. Wulfing , J. Immunol. , 2006; 177:1708-20

A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synpase

Singelton, K., Parvaze, N., Dama, K. R., Chen, K. S., Jennings, P., Purtic, B., Sjaastad, M. D., Gilpin, C., Davis, M. M., and Wulfing, C. , J. Immunol. , 2006; 177:4402-13

Regulation of sustained actin dynamics by the TCR and costimulation as a mechanism of receptor localization.

Tskvitaria-Fuller I, Rozelle AL, Yin HL, Wülfing C., J. Immunol., 2003; 171:2287

Honors/Awards

W.A. Moncrief, Jr. Scholar in Biomedical Research

(2000)

EMBO long-term fellowship

Postdoctoral Fellowship (1994)