Anne Satterthwaite, PhD

Associate Professor
Endowed Title: Southwestern Medical Foundation Scholar in Biomedical Research 1999-2003
Internal Medicine, Immunology
Graduate Program: Immunology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

anne.satterthwaite@utsouthwestern.edu

Biography

Prior to joining the UT Southwestern faculty in 2000, Dr. Anne Satterthwaite received a bachelors degree in Life Sciences from MIT and a PhD in Cell and Developmental Biology from the Division of Medical Sciences at Harvard University. She subsequently pursued postdoctoral work with Dr. Owen Witte at UCLA where she developed an interest in understanding the signaling pathways that regulate B lymphocyte development and function.

Education

Graduate SchoolHarvard University, Biology (1993)
UndergraduateMassachusetts Institute of Technology, Science (1987)

Research Interests

Autoimmunity
B cell development
Immunodeficiency
Signal transduction

Publications

Featured
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways

Satterthwaite AB, Lowell CA, Khan WN, Sideras P, Alt F, and Witte ON , Journal of Experimental Medicine , September 1998; (188/5):833-44

Featured
Btk dosage determines sensitivity to B cell antigen receptor crosslinking

Satterthwaite AB, Cheroutre H, Khan WN, Sideras P, and Witte ON , Proceedings of the National Academy of Sciences , November 1997; (94/24):13152-7

Featured
Autoreactive B Cell Responses to RNA-Related Antigens Due to TLR7 Gene Duplication

Pisitkun P, Deane JA, Difilippantonio MJ, Tarasenko T, Satterthwaite AB, and Bolland S , Science , June 2006; (312):1669-72

Featured
Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus

Wu T, Qin X, Korepa Z, Raman K, Bhaskarabhalta M, Zhou XJ, Satterthwaite AB, Davis LS, Mohan C. , J. Clin. Invest. , August 2007; (117):2186-2196

Featured
Reduced dosage of Brutons tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in Lyn-/- mice.

Whyburn LR, Halcomb KE, Contreras C, Lowell CA, Witte ON, and Satterthwaite AB , J. Immunol. , August 2003; (171):1850-58.

Foxo3-/- mice demonstrate reduced numbers of pre-B and recirculating B cells but normal splenic B cell subpopulations.

Hinman RM, Nichols WA, Diaz TM, Gallardo TD, Castriollon DH, and Satterthwaite AB , International Immunology , July 2009; (21):831-842

B cell receptor signaling down-regulates forkhead box transcription factor class O 1 mRNA expression via phosphatidylinositol 3-kinase and Brutons tyrosine kinase.

Hinman RM, Bushanam JN, Nichols WA, and Satterthwaite AB , J. Immunol. , January 2007; (178):740-7

Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells.

Halcomb KE, Musuka S, Gutierrez T, Wright HL, Satterthwaite AB , Molecular Immunology , December 2008; (46):233-241

Btk and PLCg2 can function independently during B cell development

Halcomb KE, Contreras CM, Coursey TG, Hinman RM, Wright HL, and Satterthwaite AB , Eur. J. Immunol. , April 2007; (37):1033-42

Btk regulates multiple stages in the development and survival of B-1 cells

Contreras CM, Halcomb KE, Randle L, Hinman RM, Gutierrez T, Clarke SH, and Satterthwaite AB , Mol. Immunol. , April 2007; (44):2719-28

Honors/Awards

Southwestern Medical Foundation Scholar in Biomedical Research

UT Southwestern (2000)

Leukemia and Lymphoma Society Special Fellowship

(1998)

Irvington Institute for Immunological Research Postdoctoral Fellowship

(1994)

Professional Associations/Affiliations

American Association of Immunologists