Elena Nosyreva, PhD

Instructor
Neuroscience, Physiology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-1800
Office Fax: 214-648-1801

elena.nosyreva@utsouthwestern.edu

Biography

EDUCATION

MSc in Physiology, 1976, College of Biology, St. Petersburg State University, St..Petersburg, Russia

PhD in Cytology, 1980, Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.

SUMMARY OF PROFESSIONAL EXPERIENCE

Vast research experience in physiology, neurobiology and signal transduction, wide spectrum of electrophysiological, cellular biological and biochemical skills including expertise in electrophysiology: voltage clamp technique, patch clamp technique, single channel recordings of reconstituted proteins in bilayers, extracellular recordings from mammalian brain slices and insect and mammalian neuromuscular junctions. Experience in protein expression and purification. Significant experience in molecular biology techniques. Extensive cell culture experience

POSITIONS HELD

2002- present Instructor, Department of Neuroscience, UT Southwestern

1999- 2002 Postdoctoral Fellow, Instructor, Department of Physiology, UT Southwestern

1990- 1999 Senior Scientist, Ph.D. in the Laboratory of Neuroreceptors and Neuroregulators, the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow, Russia

1981-1988 Scientist, PhD in the Lab of Ionic channels, Institute of Cytology RAS, St. Petersburg, Russia

 

Education

Graduate SchoolInstitute of Cytology - Russia (Cytology), Science (1979)
UndergraduateSt. Petersburg State University - Russia, Physiology (1976)

Publications

Featured
Developmental switch in synaptic mechanisms of hippocampal mGluR dependent long-term depression

Nosyreva E., Huber K, , J. Neuroscience , 2005; (25 (11):):2992-3001

Featured
The high-affinity calcium-calmodulin-binding site does not play a role in the modulation of type 1 inositol (1,4,5)-trisphosphate receptor function by

E. Nosyreva, T. Miyakawa, Z. Wang, L., L. Glouchankova, A. Mizushima, M. Iino and I. Bezprozvanny , Biochem.J., , 2002; (365):659-667.

Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate.

Waung MW, Pfeiffer BE, Nosyreva ED, Ronesi JA, Huber KM , Neuron , July 2008; (59(1)):84-97

Activity-Dependent Augmentation of Spontaneous Neurotransmission during Endoplasmic Reticulum Stress.

. Nosyreva E. D., Kavalali E.T. , J. Neurosci. , 2010; (30):7358-7368

Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the model of fragile x syndrome.

Nosyreva E., Huber K, , J. of Neurophysiology 95: 3291-3295. , 2006; (95):3291-3295

Developmental switch in synaptic mechanisms of hippocampal mGluR dependent long-term depression.

Nosyreva E., Huber K, , J. Neuroscience , 2005; (25 (11):):2992-3001