Peter Igarashi, MD

Professor
Endowed Title: Robert Tucker Hayes Distinguished Chair in Nephrology, in Honor of Dr. Floyd C. Rector Jr.
Internal Medicine, Pediatrics
Graduate Program: Genetics and Development
Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-2754
Office Fax: 214-648-2071

peter.igarashi@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Education

FellowshipYale University School of Medicine, Nephrology (1987)
ResidencyUniversity of California Davis Medical Center, Internal Medicine (1984)
InternshipUniversity of California Davis Medical Center, Internal Medicine (1982)
Medical SchoolUCLA School of Medicine (1981)

Research Interests

Cilia
Gene regulation
Kidney development
Knockout mice
MicroRNA
Polycystic kidney disease
Transcription factor

Publications

Featured
Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases.

Choi YH, Suzuki A, Hajarnis S, Ma Z, Chapin HC, Caplan MJ, Pontoglio M, Somlo S, Igarashi P, Proceedings of the National Academy of Sciences of the United States of America, 2011 Jun; 108 (26):10679-84

Featured
A mitotic transcriptional switch in polycystic kidney disease.

Verdeguer F, Le Corre S, Fischer E, Callens C, Garbay S, Doyen A, Igarashi P, Terzi F, Pontoglio M, Nature medicine, 2010 Jan; 16 (1):106-10

Featured
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis.

Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford JB, Carroll TJ, Nature genetics, 2009 Jul; 41 (7):793-9

Featured
HNF-1beta regulates transcription of the PKD modifier gene Kif12.

Gong Y, Ma Z, Patel V, Fischer E, Hiesberger T, Pontoglio M, Igarashi P, Journal of the American Society of Nephrology : JASN, 2009 Jan; 20 (1):41-7

Featured
Kidney cysts, pancreatic cysts, and biliary disease in a mouse model of autosomal recessive polycystic kidney disease.

Williams SS, Cobo-Stark P, James LR, Somlo S, Igarashi P, Pediatric nephrology (Berlin, Germany), 2008 May; 23 (5):733-41

Featured
Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.

Patel V, Li L, Cobo-Stark P, Shao X, Somlo S, Lin F, Igarashi P, Human molecular genetics, 2008 Jun; 17 (11):1578-90

Featured
Mutations of HNF-1beta inhibit epithelial morphogenesis through dysregulation of SOCS-3.

Ma Z, Gong Y, Patel V, Karner CM, Fischer E, Hiesberger T, Carroll TJ, Pontoglio M, Igarashi P, Proceedings of the National Academy of Sciences of the United States of America, 2007 Dec; 104 (51):20386-91

Featured
Proteolytic cleavage and nuclear translocation of fibrocystin is regulated by intracellular Ca2+ and activation of protein kinase C.

Hiesberger T, Gourley E, Erickson A, Koulen P, Ward CJ, Masyuk TV, Larusso NF, Harris PC, Igarashi P, The Journal of biological chemistry, 2006 Nov; 281 (45):34357-64

Featured
Role of the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain in Pkhd1 (ARPKD) gene transcription and renal cystogenesis.

Hiesberger T, Shao X, Gourley E, Reimann A, Pontoglio M, Igarashi P, The Journal of biological chemistry, 2005 Mar; 280 (11):10578-86

Featured
Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice.

Hiesberger T, Bai Y, Shao X, McNally BT, Sinclair AM, Tian X, Somlo S, Igarashi P, The Journal of clinical investigation, 2004 Mar; 113 (6):814-25

Honors/Awards

NIH MERIT Award

(2011)

APS Gottschalk Distinguished Lectureship

(2006)

AHA Established Investigator Award

(1995)

AHA Connecticut Affiliate New Investigator Award

(1990)

Alpha Omega Alpha

(1981)

Professional Associations/Affiliations

American Heart Association Kidney Council

American Physiological Society

American Society for Clinical Investigation

American Society of Nephrology

Association of American Physicians