Anwarul Ferdous, PhD

Assistant Professor
Internal Medicine

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

anwarul.ferdous@utsouthwestern.edu

Biography

Anwarul Ferdous is an Assistant Professor in Internal Medicine in the division of Cardiology. He graduated from Tokyo Institute of Technology in Japan with a PhD degree in 1996. From 1997-1999 he was a lecturer in the Department of Biomolecular Engineering and Biotechnology at the same institution.

He was a postdoctoral researcher in the Center for Biomedical Invention, department of Internal Medicine at UT Southwestern from 1999-2005. He then worked as an Assistant Professor in the Cardiology division of Internal Medicine from 2005-2007. For a short time he worked as an Assistant Professor in the Division of Cardiology at the University of Minnesota, Minneapolis. He returned to UT Southwestern in 2009.

Education

Graduate SchoolTokyo Institute of Tech, English (1996)
Graduate SchoolDhaka University, Biochemistry (1987)
UndergraduateDhaka University, Biochemistry (1986)

Research Interests

Genetic manipulation of cell and mouse to evaluate the biological function of a gene
Mechanism of transcriptional regulation of gene expression
Regulation of transcriptional activity of transactivators by post-translational modifications

Publications

Featured
Phosphorylation and mono-ubiquitination of the Gal4 DNA-binding domain are essential for efficient promoter occupancy

Ferdous, A., ONeal, M., Nalley, K., Sikder, D., Johnston, S. A. and Kodadek , Mol. Biosys , 2008; (11):1116-1125

Featured
The role of the proteasomal ATPases and activator monoubiquitylation in regulating Gal4 binding to promoter

Ferdous, A., Sikder, D., Gillette, T. G., Nalley, K., Kodadek, T., and Johnston, S. A. , Genes Dev , 2007; (21):112-123

Featured
The 19S regulatory subunit of the 26S proteasome is required for efficient activated transcription by human RNA polymerase II

Ferdous, A., Kodadek, T., Johnston, S. A. , Biochemistry , 2002; (41):12798-12805

Featured
The 19S regulatory particle of the proteasome is required for efficient transcription elongation by RNA Polymerase II

Ferdous, A., Gonzalez, F., Sun, L., Kodadek, T., and Johnston, S. A. , Mol. Cell , 2001; (7):981-991

Phosphorylation of the Gal4 DNA-binding domain is essential for activator mono-ubiquitylation and efficient promoter occupancy.

Ferdous A, ONeal M, Nalley K, Sikder D, Kodadek T, Johnston SA. , Mol Biosyst. , November 2008; (2008 Nov;4(11)):1116-25

Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo.

Ferdous A, Caprioli A, Iacovino M, Martin CM, Morris J, Richardson JA, Latif S, Hammer RE, Harvey RP, Olson EN, Kyba M, Garry DJ , Proc Natl Acad Sci U S A. , January 2009; (2009 Jan 20;106(3)):814-9

Physical and functional interactions of monoubiquitylated transactivators with the proteasome.

Archer CT, Burdine L, Liu B, Ferdous A, Johnston SA, Kodadek T , J Biol Chem. , August 2008; (2008 Aug 1;283(31)):21789-98

Phosphorylation and mono-ubiquitination of the Gal4 DNA-binding domain are essential for efficient promoter occupancy

Ferdous, A., ONeal, M., Nalley, K., Sikder, D., Johnston, S. A. and Kodadek , Mol. Biosys , 2008; (11):1116-1125

Honors/Awards

March of Dime-Basil Oconner Starter

Scholar Research Award (2009)

Lillihei Heart Institute Endowed Scholar

(2007)

Monbusho Scholarship from 1993-1996

The Ministry of Education, Science and Culture of Japan (1993)

Deans honour award of 1983 and 1984 of Dhaka University

(1983)