Dawen Zhao, MD, PhD

Associate Professor
Radiology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-9621
Office Fax: 214-648-4538

dawen.zhao@utsouthwestern.edu

Biography

Dr. Zhao obtained his M.D. degree from Dalian Medical University, China and earned his Ph.D. degree in Medical Science studying brain tumor biology and MRI at Department of Neurosurgery of University of Tsukuba, Japan in 1998. After completing his postdoctoral training, he joined the faculty of Radiology in 2002 and now an Associate Professor of Radiology at UT Southwestern Medical Center. Dr. Zhao’s current research is focusing on application of multimodal imaging approaches to obtaining integrative information about anatomy, physiology and molecular events of intracranial tumor models. Dr. Zhao has diverse interests in cancer research ranging from microscopic histology to animal models and in vivo multimodal imaging techniques.

 

 

Education

Graduate SchoolUniversity of Tsukuba (1998)
Graduate SchoolDalian Medical University, Medicine (1991)

Research Interests

In vivo MR imaging of tumor vascular perfusion and permeability and tumor hypoxia in brain tumor models
In vivo multimodal molecular imaging of tumor biomarkers

Publications

Featured
In vivo near-infrared spectroscopy and magnetic resonance imaging monitoring of tumor response to combretastatin A-4-phosphate correlated with therapeutic outcome.

Zhao D, Chang CH, Kim JG, Liu H, Mason RP, International journal of radiation oncology, biology, physics, 2011 Jun; 80 (2):574-81

Featured
Near-infrared Optical Imaging of Exposed Phosphatidylserine in a Mouse Glioma Model.

Zhao D, Stafford JH, Zhou H, Thorpe PE, Translational oncology, 2011 Dec; 4 (6):355-64

Featured
In vivo Bioluminescence Imaging of Tumor Hypoxia Dynamics of Breast Cancer Brain Metastasis in a Mouse Model.

Saha D, Dunn H, Zhou H, Harada H, Hiraoka M, Mason RP, Zhao D, Journal of visualized experiments : JoVE, 2011 ; (56)

Featured
Dynamic near-infrared optical imaging of 2-deoxyglucose uptake by intracranial glioma of athymic mice.

Zhou H, Luby-Phelps K, Mickey BE, Habib AA, Mason RP, Zhao D, PloS one, 2009 ; 4 (11):e8051

Featured
Pten haploinsufficiency accelerates formation of high-grade astrocytomas.

Kwon CH, Zhao D, Chen J, Alcantara S, Li Y, Burns DK, Mason RP, Lee EY, Wu H, Parada LF, Cancer research, 2008 May; 68 (9):3286-94

A perspective on vascular disrupting agents that interact with tubulin: preclinical tumor imaging and biological assessment.

Mason RP, Zhao D, Liu L, Trawick ML, Pinney KG, Integrative biology : quantitative biosciences from nano to macro, 2011 Apr; 3 (4):375-87

Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance.

Hatanpaa KJ, Burma S, Zhao D, Habib AA, Neoplasia (New York, N.Y.), 2010 Sep; 12 (9):675-84

Multimodality imaging of hypoxia in preclinical settings.

Mason RP, Zhao D, Pacheco-Torres J, Cui W, Kodibagkar VD, Gulaka PK, Hao G, Thorpe P, Hahn EW, Peschke P, The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology, 2010 Jun; 54 (3):259-80

RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN.

Park S, Zhao D, Hatanpaa KJ, Mickey BE, Saha D, Boothman DA, Story MD, Wong ET, Burma S, Georgescu MM, Rangnekar VM, Chauncey SS, Habib AA, Cancer research, 2009 May; 69 (10):4107-11

The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma.

Park S, Hatanpaa KJ, Xie Y, Mickey BE, Madden CJ, Raisanen JM, Ramnarain DB, Xiao G, Saha D, Boothman DA, Zhao D, Bachoo RM, Pieper RO, Habib AA, Cancer research, 2009 Apr; 69 (7):2809-16

Honors/Awards

DOD Prostate Cancer Research Initiative Postdoctoral Fellowship Award

(2001)

Professional Associations/Affiliations

World Molecular Imaging Society

(2009)

International Society for Magnetic Resonance in Medicine (ISMRM)

(2002)