Klotho deficiency causes vascular calcification in chronic kidney disease.

Hu MC, Shi M, Zhang J, Griffith C, Quiñones H, Kuro-O M, Moe OW, JASN, 2011; 22:124-136

FGF23 induces left ventricular hypertrophy.

Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-O M, Kusek JW, Keane MG, Wolf M, J Clin Invest, 2011; 121:4393-4408

Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective.

Hu MC, Shi M, Zhang J, Quiñones H, Kuro-O M, Moe OW, Kidney Int, 2010; 78:1240-1251

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule.

Hu MC, Shi M, Zhang J, Pastor J, Nakatani T, Lanske B, Shawkat Razzaque M, Rosenblatt KP, Baum MG, Kuro-O M, Moe OW, FASB J, 2010; 24:3438-3450

Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation.

Goetz R, Nakadab Y, Hu MC, Kurosu H, Wang L, Nakatani T, Shi M, Eliseenkova AV, Razzaque MS, Moe OW, Kuro-o M, Mohammadi M , PNAS, 2010; 107:407-412

The reduction of Na/H exchanger-3 protein and transcript expression in acute ischemia-reperfusion injury is mediated by extractable tissue factor(s).

Di Sole F, Hu MC, Zhang J, Babich V, Bobulescu IA, Shi M, McLeroy P, Rogers TE, Moe OW, Kidney Int, 2011; 80:822-831

Klotho and kidney disease.

Hu MC, Kuro-o M, Moe OW, J Nephrol, 2010; 16:S136-S144

Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho.

Cha SK, Hu MC, Kurosu H, Kuro-o M, Moe O, Huang CL, Mol Pharmacol, 2009; 76:38-46

Effect of claudins 6 and 9 on paracellular permeability in MDCK II cells.

Sas D, Hu MC, Moe OW, Baum M, Am J Physiol Regul Integr Comp Physiol, 2008; 295:R1713-1719

GLI3-dependent transcriptional repression of GLI1 and GLI2 and kidney patterning genes disrupts renal morphogenesis.

Hu MC, Mo R, Bhella S, Chung PT, Hui CC, Rosenblum ND, Development, 2006; 133:569-578