Xuelian Luo, PhD

Assistant Professor
Pharmacology
Graduate Program: Molecular Biophysics

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-6368
Office Fax: 214-645-6138

xuelian.luo@utsouthwestern.edu

Education

Graduate SchoolTufts University, Biochemistry (1997)
UndergraduatePeking University - China, Chemistry (1990)

Research Interests

Cell cycle checkpoints and cancer
Nuclear Magnetic Resonance (NMR) spectroscopy
Organ size control and cancer
Structural biology
X-ray crystallography

Publications

Featured
Structural and functional analysis of the YAP-binding domain of human TEAD2.

Tian W, Yu J, Tomchick DR, Pan D, Luo X, Proceedings of the National Academy of Sciences of the United States of America, 2010 Apr; 107 (16):7293-8

Featured
Insights into mad2 regulation in the spindle checkpoint revealed by the crystal structure of the symmetric mad2 dimer.

Yang M, Li B, Liu CJ, Tomchick DR, Machius M, Rizo J, Yu H, Luo X, PLoS biology, 2008 Mar; 6 (3):e50

Featured
Blockage of Mad2 Activation by p31comet through Structural Mimicry.

Yang, M., Li, B., Tomchick, DR., Machius, M., Rizo, J., Yu, H. & Luo, X. , Cell , 2007; (131):744-755

Featured
The Mad2 Spindle Checkpoint Protein Has Two Distinct Natively Folded States.

Luo, X., Tang, Z., Xia, G., Wassmann, K., Matsumoto, T., Rizo, J., and Yu, H. , Nat. Struct. Mol. Biol. , 2004; (4):338-45

Featured
The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20.

Luo, X., Tang, Z., Rizo, J., and Yu, H. , Mol. Cell , 2002; (9):59-71

Snapshots of a hybrid transcription factor in the Hippo pathway.

Luo X, Protein & cell, 2010 Sep; 1 (9):811-9

Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition.

Kim S, Sun H, Ball HL, Wassmann K, Luo X, Yu H, Proceedings of the National Academy of Sciences of the United States of America, 2010 Nov; 107 (46):19772-7

Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition.

Kim S, Sun H, Ball HL, Wassmann K, Luo X, Yu H, Proceedings of the National Academy of Sciences of the United States of America, 2010 Nov; 107 (46):19772-7

Protein metamorphosis: the two-state behavior of Mad2.

Luo X, Yu H, Structure (London, England : 1993), 2008 Nov; 16 (11):1616-25

Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20.

Luo, X., Fang, G., Coldiron, M., Lin, Y., Yu, H., Kirschner, M. W. and Wagner, G. , Nat. Struct. Biol. , 2000; (7):224-229

Honors/Awards

National Cancer Institute

Howard Temin Award, 2003-2008 (2003)