Hongtao Yu, PhD

Professor
Endowed Title: Michael L. Rosenberg Scholar in Medical Research 1998-2002
Pharmacology
Graduate Program: Cell Regulation
Molecular Biophysics

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-6161
Office Fax: 214-645-6156

hongtao.yu@utsouthwestern.edu

Biography

Dr. Hongtao Yu was born in China in 1969. He received his B.S. in Chemistry from Peking University (Beijing, China). He came to the U.S. in 1990 and received his Ph.D. in Chemistry from Harvard University (Cambridge, MA) in 1995. His thesis research focused on the structure determination of protein modules involved in signal transduction. He then completed his postdoctoral training in Biology at Harvard Medical School (1995-1999). During his postdoctoral training, Dr. Yu studied the regulation of the cell division cycle in vertebrates. In 1999, Dr. Yu began his independent research career as an Assistant Professor and the Michael L. Rosenberg Scholar in Biomedical Research at the Department of Pharmacology at UT Southwestern Medical Center. He was promoted to Associate Professor with tenure in 2004 and to Professor in 2008. He was selected as an HHMI Investigator in 2008. His lab studies cellular mechanisms that govern chromosome inheritance and integrity using a combination of cell biological, biochemical, and biophysical methods.

Education

Graduate SchoolHarvard University, Chemistry (1995)
UndergraduatePeking University - China, Chemistry (1990)

Research Interests

Cell cycle checkpoints
Chromosome segregation
DNA repair
Histone modifications
Protein structure and folding

Publications

Featured
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation

Tang, Z., Shu, H., Qi, W., Mahmood, N., Mumby, M. C., and Yu, H. , Dev. Cell , 2006; (10):575-585

Featured
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.

Tang, Z., Sun, Y., Harley, S. E., Zou, H., and Yu, H. , Mol. Cell , 2004; (16):387-397

Featured
The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20.

Luo, X., Tang, Z., Rizo, J., and Yu, H. , Mol. Cell , 2002; (9):59-71

Featured
Identification of a cullin homology region in a subunit of the Anaphase-Promoting Complex.

Yu, H., Peters, J.P., King, R. W., Page, A., Hieter, P., and Kirschner, M. W. , Science , 1998; (279):1219-1222

Featured
Structural basis for the binding of proline-rich peptides to SH3 domains.

Yu, H., Chen, J. K., Feng, S., Dalgarno, D. C., Brauer, A. W. and Schreiber, S. L. , Cell , 1994; (76):933-945

PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution.

Ke Y, Huh JW, Warrington R, Li B, Wu N, Leng M, Zhang J, Ball HL, Li B, Yu H, The EMBO journal, 2011 Jul; :3309-21

The SMC5/6 complex maintains telomere length in ALT cancer cells through sumoylation of telomere-binding proteins

Potts, P. R. and Yu, H. , Nat. Struct. Mol. Biol. , 2007; (14):581-590

PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.

Tang, Z., Shu, H., Qi, W., Mahmood, N., Mumby, M. C., and Yu, H. , Dev. Cell , 2006; (10):575-585

Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase

Yang, M., Gocke, C. B., Luo, X., Borek, D., Tomchick, D. R., Machius, M., Otwinowski, Z., and Yu, H. , Mol. Cell , 2006; (23):377-387

Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.

Tang, Z., Shu, H., Oncel, D., Chen, S., and Yu, H. , Mol. Cell , 2004; (16):387-397

Honors/Awards

The Leukemia & Lymphoma Society

Scholar Award (2003)

W.M. Keck

Scholar Award (2003)

Burroughs Wellcome

New Investigator Award in Pharmacological Science (2000)

Packard Fellowship

Science and Engineering (2000)

Damon Runyon

Scholar Award (1999)

Professional Associations/Affiliations

American Association for the Advancement of Science

American Society for Cell Biology

Sigma Xi