Richard Bruick, PhD

Associate Professor
Endowed Title: Michael L. Rosenberg Scholar in Medical Research 2002-2006
Biochemistry
Graduate Program: Biological Chemistry
Cancer Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-6477
Office Fax: 214-648-0320

richard.bruick@utsouthwestern.edu

Education

Graduate SchoolScripps Research Institute, Biology (1998)
UndergraduateUniversity of North Carolina at Chapel Hill, Chemistry (1991)

Research Interests

Cancer
Cellular sensors of environmental and metabolic cues
Regulation of mammalian iron homeostasis
Regulation of mammalian oxygen homeostasis

Publications

Featured
An E3 Ligase Possessing an Iron Responsive Hemerythrin Domain is a Regulator of Iron Homeostasis

Salahudeen, A.A., Thompson, J.W., Ruiz, J.C., Ma, H., Kinch, L.N., Li, Q., Grishin, N.V, and Bruick, R.K. , Science , 2009; (326):722-726

Featured
The candidate tumor suppressor ING4 represses activation of the Hypoxia Inducible Factor (HIF)

Ozer, A., Wu, L.C., and Bruick R.K. , Proc. Natl. Acad. Sci. USA. , 2005; (102):7481-7486

Featured
Functions of the Per/ARNT/Sim (PAS) Domains of the Hypoxia Inducible Factor (HIF)

Yang, J., Zhang, L., Erbel, P.J.A., Gardner, K.H., Ding, K., Garcia, J.A., and Bruick, R.K. , J. Biol. Chem. , 2005; (280):36047-36054

Featured
FIH-1 is an asparaginyl hydroxylase that regulates HIF transcriptional activity

Peet, D.J., Lando, D., Whelan, D.A., Gorman, J.J., Whitelaw, M.L. and Bruick, R.K. , Genes & Dev. , 2002; (16):1466-1471

Featured
A conserved family of prolyl-4-hydroxylases that modify HIF

Bruick, R.K. and McKnight, S.L. , Science , 2001; (294):1337-1340

An E3 Ligase Possessing an Iron Responsive Hemerythrin Domain is a Regulator of Iron Homeostasis

Salahudeen, A.A., Thompson, J.W., Ruiz, J.C., Ma, H., Kinch, L.N., Li, Q., Grishin, N.V, and Bruick, R.K. , Science , 2009; (326):722-726

Maintaining Mammalian Iron and Oxygen Homeostasis: Sensors, Regulation, and Crosstalk

Salahudeen, A.S., and Bruick, R.K. , Annals of the New York Acad. Sci. , 2009; (1177):30-38

Artificial Ligand Binding within the HIF2α PAS-B Domain of the HIF2 Transcription Factor

Scheuermann, T.H., Tomchick, D.R., Machius, M., Guo, Y., Bruick, R.K., and Gardner, K.H. , Proc. Natl. Acad. Sci. USA. , 2009; (106):450-455

JMJD6 is a Histone Arginine Demethylase

Chang, B., Chen, Y., Zhao, Y., and Bruick, R.K. , Science , 2007; (318):444-447

Hypoxia Stimulates Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase through Accumulation of Lanosterol and Hypoxia-Inducible Factor-mediated Induction of Insigs

Nguyen, A.D., McDonald, J.G., Bruick, R.K., and Debose-Boyd, R.A. , J. Biol. Chem. , 2007; (282):27436-27446

Honors/Awards

Young Investigator Award

American Cancer Society (2004)

Distinguished Young Researcher Award

President’s Research Council (2003)

Career Award in the Biomedical Sciences

Burroughs Wellcome Fund (2002)

Michael L. Rosenberg Scholar in Medical Research

(2002)