Kathlynn Brown, PhD

Assistant Professor
Internal Medicine, Simmons Comprehensive Cancer Center
Graduate Program: Cancer Biology
Cell Regulation

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

kathlynn.brown@utsouthwestern.edu

Education

Graduate SchoolUniversity of Texas at Austin, Chemistry
UndergraduateTrinity Valley Community College, Chemistry

Research Interests

cancer biomarker identification
cell-specific targeting
drug delivery
lung cancer
receptor-ligand interactions

Publications

Featured
Cell-Specific Delivery of a Chemotherapeutic to Lung Cancer Cells

Zhou, Xin; Chang, Ya-Ching; Oyama, Tsukasa; McGuire, Michael J.; Brown, Kathlynn C. , Journal of the American Chemical Society , 2004; (126):15656-15657

Featured
Isolation of Lung Tumor Specific Peptides from a Random Library: Generation of Diagnostic and Cell-targeting Reagents

Oyama, Tsukasa, Sykes, Kathryn F., Samli, Kausar, N., Minna, John D., Johnston, Stephen Albert, Brown, Kathlynn C , Cancer Lett. , 2003; (202):219-230

Featured
Determining Protein-Protein Interactions by Oxidative Cross-linking of a GGH-Fusion Protein

Brown, Kathlynn C.; Yu, Zhonghua; Burlingame, Alma L.; Craik, Charles S. , Biochemistry , 1998; (37):4397-4406

Featured
Highly Specific Oxidative Crosslinking of Proteins Mediated by a Nickel-Peptide Complex

Brown, Kathlynn C.; Yang, Sang-Hwa; and Kodadek, Thomas , Biochemistry , 1995; (34):4733-4739

Featured
Mechanism of the Rhodium Porphyrin-Catalyzed Cyclopropanation of Alkenes: Spectroscopic and Kinetic Characterization of Organometallic Intermediates

Maxwell, Jana L.; Brown, Kathlynn C.; Bartley, David W. and Kodadek, Thomas , Science , 1992; (256):1544-1547

Isolation of multiple cell-binding ligands from different phage displayed-peptide libraries

Oyama, Tsukasa; Rombel, Irene T.; Samli, Kausar N.; Zhou Xin; Brown, Kathlynn C. , Biosensors & Bioelectronics , Winter 2006; (21):1867-1875

Novel Ligands for Cancer Diagnosis: Selection of Peptide Ligands for Identification and Isolation of B-Cell Lymphomas

McGuire, Michael J.; Samli, Kausar N.; Chang Ya-Ching; Brown Kathlynn C. , Experimental Hematology , Winter 2006; (34):443-452

A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for non-small cell lung cancer

Elayadi, Anissa N.; Samli, Kausar N.; Prudkin, Ludmila; Liu, Ying-horng; Bian, Aihua; Xie, Xian-Jin; Wistuba, Ignacio I.; Roth, Jack A.; McGuire, Michael J.; Brown, Kathlynn C. , Cancer Research , Summer 2007; (67):5889-5895

Peptide-Mediated Targeting of the Islets of Langerhans

Samli, Kausar N.; McGuire, Michael J.; Newgard, Christopher B.; Johnston, Stephen Albert; Brown, Kathlynn C , Diabetes , 2005; (54):2103-2108

A Library-Selected, Langerhans Cell-Targeting Peptide Enhances an Immune Response

McGuire, Michael J.; Sykes, Kathryn F.; Samli, Kausar N.; Timares, Laura; Barry, Michael A.; Stemke-Hale, Katherine; Tagliaferri, Frank; Logan, Mark; Jansa, Kimberly; Takashima, Akira; Brown, Kathlynn C.; Johnston, Stephen Albert , DNA Cell Biol. , 2004; (23):742-752

Honors/Awards

Damon Runyon-Walter Winchell Foundation Postdoctoral Research Fellowship

(1994)

American Chemical Society Organic Division Fellowship

(1993)

Professional Associations/Affiliations

American Association of Cancer Researchers

American Chemical Society