Are You a Faculty Member?
If you are a faculty member and would like to make a change to your faculty profile, please login to Profile+ with your UT Southwestern Id and password. Questions? Please email Web Services.
Ward Wakeland, PhD
Endowed Title: Edwin L. Cox Distinguished Chair in Immunology and Genetics
Contact Information
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390
Office Phone: 214-648-7330
Office Fax: 214-648-7331
Biography
My laboratory utilizes mouse genetics to delineate the genetic basis for autoimmune disease pathogenesis. Our primary focus has been on systemic lupus erythematosus (SLE), a debilitating autoimmune disease initiated via a profound loss of immunologic tolerance to nuclear antigens. We have used genetic manipulation of the lupus-prone NZM2410 murine model of SLE to dissect SLE pathogenesis into a series of discrete stages.
We are currently in the process of identifying the individual susceptibility genes and defining the genetic pathways responsible for the initiation and progression of systemic autoimmunity in lupus-prone mouse models of SLE. Additional projects within the laboratory include genetic dissections of autoimmune diabetes and the analysis of a variety of polymorphisms in normal immune functions.
The use of microarray technology in combination with genetic fine mapping to identify polymorphic genes with potent immunologic effects is a major new thrust within the laboratory. There are currently six postdoctoral fellows, five graduate students, and eight technicians in our research group. I strongly encourage all postdoctoral fellows and students to obtain research fellowships as a component of their training.
Education
| Graduate School | University of Hawaii at Hilo, Microbiology (1976) |
Research Interests
Publications
Subramanian, S., Tus, K., Li, Q.-Z., Wang, A., Tain, X.-H., Zhou, J., Liang, C., Barov, G., McDaniel, L.D., Zhou, X.J., Schultz, R.A., and Wakeland, E.K. , Proc. Natl. Acad. Sci. , 2006; (103):9970-9975
Kumar, K.R., Li, L., Yan, M, Bhaskarabhatla, M., Mobley, A.B., Nguyen, C., Mooney, J.M., Schatzle, J.D., Wakeland, E.K, and Mohan, C. , Science , 2006; (312):1665-1669