Kevin Gardner, PhD

Professor
Endowed Title: W.W. Caruth, Jr. Scholar in Biomedical Research 1998-2002
Virginia Lazenby O'Hara Chair in Biochemistry
Biochemistry, Pharmacology
Graduate Program: Biological Chemistry
Molecular Biophysics

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-645-6365
Office Fax: 214-645-6353

kevin.gardner@utsouthwestern.edu

Biography

For more information, check out the Gardner lab website.

Kevin Gardner is the Virginia Lazenby O’Hara Chair in Biochemistry and W.W. Caruth Jr. Scholar in Biomedical Research at the UT Southwestern Medical Center in Dallas.  Dr. Gardner joined the UT Southwestern faculty in 1998 after B.S. (UC Davis, 1989), Ph.D. (Yale, 1995) and postdoctoral (Univ. Toronto with Lewis Kay, 1998) studies in biophysics and biochemistry.  His research group integrates structural, dynamic and kinetic information from solution NMR studies with other biophysical and biochemical data to probe the signaling mechanisms of environmental sensory proteins.  This research aims to decipher how similar proteins sense different stimuli – e.g. blue light, oxygen – to control different output functions.  Such studies lay the foundation for both understanding the natural regulation of these systems and artificially controlling them.

Education

Graduate SchoolYale University, Biophysics (1995)
UndergraduateUniversity of California-Davis, Biochemistry (1989)

Research Interests

allostery
artificial regulation
biomolecular NMR
cancer
photosensors
signaling
structural biology

Publications

Featured
Structural basis of photosensitivity in a bacterial light-oxygen-voltage/helix-turn-helix (LOV-HTH) DNA-binding protein.

Nash AI, McNulty R, Shillito ME, Swartz TE, Bogomolni RA, Luecke H, Gardner KH, Proceedings of the National Academy of Sciences of the United States of America, 2011 Jun; 108 (23):9449-54

Featured
Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B.

Partch CL, Gardner KH, Proceedings of the National Academy of Sciences of the United States of America, 2011 May; 108 (19):7739-44

Featured
Structural basis of a phototropin light switch.

Harper SM, Neil LC, Gardner KH, Science (New York, N.Y.), 2003 Sep; 301 (5639):1541-4

Mutational and Structural Studies of the PixD BLUF Output Signal That Affects Light-Regulated Interactions with PixE.

Yuan H, Dragnea V, Wu Q, Gardner KH, Bauer CE, Biochemistry, 2011 Jul; 50 (29):6365-75

Modulating LOV domain photodynamics with a residue alteration outside the chromophore binding site.

Song SH, Freddolino PL, Nash AI, Carroll EC, Schulten K, Gardner KH, Larsen DS, Biochemistry, 2011 Apr; 50 (13):2411-23

The three Rs of transcription: recruit, retain, and recycle.

Motta-Mena LB, Partch CL, Gardner KH, Molecular cell, 2010 Dec; 40 (6):855-8

Rationally improving LOV domain-based photoswitches.

Strickland D, Yao X, Gawlak G, Rosen MK, Gardner KH, Sosnick TR, Nature methods, 2010 Aug; 7 (8):623-6

Coactivator recruitment: a new role for PAS domains in transcriptional regulation by the bHLH-PAS family.

Partch CL, Gardner KH, Journal of cellular physiology, 2010 Jun; 223 (3):553-7

Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT).

Partch CL, Card PB, Amezcua CA, Gardner KH, The Journal of biological chemistry, 2009 May; 284 (22):15184-92

Honors/Awards

UT Southwestern - Postdoctoral Association

Excellence in Postdoctoral Mentoring Award (2011)

UT Southwestern Medical Center

Virginia Lazenby O’Hara Chair in Biochemistry (2006)

The Chicago Community Trust

Searle Scholar (1999)

UT Southwestern Medical Center

W.W. Caruth, Jr. Scholar in Biomedical Research (1998)

Helen Hay Whitney Foundation

Postdoctoral Fellowship (1996)

NIH

NRSA Postdoctoral Fellowship (1995)

HHMI

Predoctoral Fellowship - Structural Biology (1989)

Professional Associations/Affiliations

American Chemical Society

Biophysical Society