Guosheng Liang, PhD

Assistant Professor
Molecular Genetics
Graduate Program: Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-2141
Office Fax: 214-648-8804

guosheng.liang@utsouthwestern.edu

Biography

Dr. Liang was born in a small farming village of LeiYang (Hunan, P.R. China). He graduated from the second middle school of LeiYang in 1987 and attended Peking University. After graduating with a BS in Biochemistry in July 1991, he came to the US to study at Ohio State University, where he obtained his PhD in Biochemistry in December 1997.

From 1998 to 2002, Dr. Liang did postdoctoral research in the laboratory of Drs. Michael Brown and Joseph Goldstein at UT Southwestern. From July 2002 to September 2004, he worked as a research assistant professor at Molecular Genetics Department at UT Southwestern. From September 2004 to June 2005, he did drug-discovery research as a senior scientist at Eli Lilly.

Since July 2005, he has been an assistant professor in the Department of Molecular Genetics.

Education

Graduate SchoolOhio State University-Main Campus (1997)
UndergraduatePeking University - China (1991)

Research Interests

Cholesterol homeostasis
Metabolic diseases such as obesity and diabetes
Transcriptional regulation

Publications

Featured
Schoenheimer effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.

Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS. , J Clin Invest. , September 2005; (115(9)):2489-98

Featured
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.

Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ. , Genes Dev. , November 2000; (14(22)):2819-30.

Featured
Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c.

Liang G, Yang J, Horton JD, Hammer RE, Goldstein JL, Brown MS. , J Biol Chem. , March 2002; (277(11)):9520-8

Featured
Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver.

Kuriyama H, Liang G, Engelking LJ, Horton JD, Goldstein JL, Brown MS. , Cell Metab. , January 2005; (1(1)):41-51

Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice.

Guan,H.P., Goldstein, J.L., Brown, M.S., and Liang, G. , J. Biol. Chem. , September 2009; (284):24644-52

Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin

Engelking, L.J., Evers, B.M., Richardson, J.A., Goldstein, J.L., Brown, M.S. and Liang, G. , J. Clin. Invest. , September 2006; (116):2356-2365

Schoenheimer effect explained - feedback regulation of cholesterol synthesis in mice mediated by Insig proteins

Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS. , J Clin Invest , September 2005; (115 (9)):2489-2498

Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver.

Kuriyama H, Liang G, Engelking LJ, Horton JD, Goldstein JL, Brown MS. , Cell Metab , January 2005; (1(1)):41-51

Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone.

Yang, J., Brown, M.S., Liang, G., Grishin, N.V., Goldstein, J.L. , Cell , 2008; (132):387-396

Honors/Awards

The Hartwell Individual Biomedical Research Award

(2006)

University Fellowship, Ohio State University

(1991)