Pradeep Mammen, MD

Assistant Professor
Internal Medicine
Graduate Program: Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

pradeep.mammen@utsouthwestern.edu

To make an appointment, call 214-645-8300.

Biography

Dr. Mammen received his Bachelor in Science and Engineering in Bioengineering at the University of Pennsylvania and his Medical Doctorate at the University of Wisconsin-Madison. He completed an Internal Medicine Residency at the University of Iowa Hospitals & Clinics. In 1998 he arrived at UT Southwestern Medical Center where he completed Fellowships in General Clinical Cardiology, Molecular Cardiology, and Clinical Heart Failure/Cardiac Transplantation. Dr. Mammen’s clinical and scientific focus revolves around heart failure/transplantation.

Education

FellowshipUT Southwestern Medical Center at Dallas, Heart Failure / Cardiac Transplant (2004)
FellowshipUT Southwestern Medical Center at Dallas, Molecular Cardiology (2004)
FellowshipUT Southwestern Medical Center at Dallas, Cardiology (2001)
ResidencyUniversity of Iowa Hospitals and Clinics, Internal Medicine (1998)
InternshipUniversity of Iowa Hospitals and Clinics, Internal Medicine (1996)
Medical SchoolUniversity of Wisconsin School of Medicine (1995)

Research Interests

Cardiac energetics
Modulation of the metabolic and redox states with stressed cardiomyocytes
Oxidative stress
Oxygen and nitric oxide metabolism in the heart
Regenerative Medicine

Publications

Featured
LXRs: Double agents in the regulation of dietary fat and cholesterol metabolism.

Kalaany N.Y, K.C. Gauthier, A.M. Zavacki, P.P.A. Mammen, T. Kitazume, J.A. Peterson, D.J. Garry, A.C. Bianco, and D.J. Mangelsdorf. , Cell Metabolism , 2005; (1):231-244

Featured
Emerging roles of myoglobin in the heart.

Garry D.J., S.B. Kanatous, and P.P.A. Mammen , Trends in Cardiovascular Medicine , 2003; (13):111-116

Featured
Hypoxia-induced left ventricular dysfunction in myoglobin deficient mice.

Mammen P.P.A., S.B. Kanatous, I. Yuhanna, P. W. Shaul, R.S. Balaban, M.G. Garry, and D.J. Garry , Am J Physiol: Heart and Circulatory Physiology , 2003; (285):H2132-2141

Featured
Myocyte-enriched calcineurin interacting protein, MCIP1, inhibits cardiac hypertrophy.

Rothermel B.A., T.A. McKinsey, R.B. Vega, R.L.Nicol, P. Mammen, J. Yang, C. Antos, J.M. Shelton, R. Bassel-Duby, E.N. Olson, and R.S. Williams. , Proceedings of the National Academy of Sciences USA , 2001; (98):3328-3333

Featured
Adaptive mechanisms that preserve cardiac function in mice without myoglobin.

Meeson A., N. Radford, J.M. Shelton, P.P.A. Mammen, Y.Kong, J.M. DiMaio, K. Hutcheson, J. Elterman, R.S. Williams, and D.J. Garry , Circulation Research , 2001; (88):713-720

Hypoxia reprograms calcium signaling and regulates myoglobin expression.

Kanatous, S.B., P.P.A. Mammen, P.B. Rosenberg, C.M. Martin, M.D. White, J.M. DiMaio, G Huang, S. Muallem, and D.J. Garry , American Journal of Physiology - Cell Physiology , November 2008; (In Press):Presently online

Association of Cystatin C with left ventricular structure and function: The Dallas Heart Study.

Patel, P.C., S.A. Murphy, R. Peshock, A. Khera, J.A. de Lemos, J.A. Balko, S Gupta, P.P.A. Mammen, M.H. Drazner, and D.W. Markham. , Circulation-Heart Failure , February 2009; (In Press):Online February 10, 2009

Calcineurin activates cytoglobin transcription in hypoxic myocytes.

Singh S.*, S.M. Manda*, D. Sikder, M.J. Birrer, B.A. Rothermel, D.J. Garry, and P.P.A. Mammen. , Journal of Biological Chemistry , February 2009; (In Press):Online February 9, 2009

Fulminant myocarditis.

Gupta S., D.W. Markham, M.H. Drazner, and P.P.A. Mammen , Nature Clinical Practice Cardiovascular Medicine , 2008; (5(11)):693-706

Cytoglobin: A novel stress-responsive hemoprotein that is expressed in the developing and adult brain.

Mammen P.P.A., J.M Shelton, Q. Ye, S.B. Kanatous, A.J. McGrath, J.A. Richardson, and D.J. Garry , Journal of Histochemistry & Cytochemistry , 2006; (54(12)):1349-1361

Honors/Awards

Postdoctoral Mentor to Sarvjeet Singh, PhD, a Finalist for the Louis N. and Arnold M. Katz Basic Science Research Award

Highest basic science award given to a junior investigator. The award is sponsored by the American Heart Assoication (2010)

2nd Place, Northwestern University Feinberg School of Medicine Cardiovascular Young Investigators’ Forum

Outstanding research as a junior faculty member (2006)

GlaxoSmithKline Competitive Grant Award for Young Investigators

One of four cardiovascular investigators in the nation to receive this competitive grant. (2005)

Above and Beyond the Call of Duty Award

Recognition for compassionate care (U. of Iowa Hospitals & Clinics) (1998)

Ernest O. Theilen Award

Outstanding Cardiac Care Unit Resident of the Year (U. of Iowa Hospitals & Clinics) (1998)

Professional Associations/Affiliations

American College of Cardiology (Fellow)

American College of Physicians (Member)

American Heart Association (Member)

Heart Failure Society of America (Member)

International Society of Heart and Lung Transplantation (Member)