Makoto Kuro-o, MD, PhD

Associate Professor
Endowed Title: Kern and Marnie Wildenthal President's Research Council Professorship in Medical Science
Southwestern Medical Foundation Scholar in Biomedical Research 1998-2002
Pathology
Graduate Program: Integrative Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-4018
Office Fax: 214-648-4070

makoto.kuro-o@utsouthwestern.edu

Biography

Higher Education:

1985 MD, University of Tokyo

1991 PhD, University of Tokyo

Academic Appointments:

1985-86 Intern, Tokyo University Hospital.

1986-87 Intern, Tokyo Metropolitan Geriatric Hospital.

1987-88 Resident in Internal Medicine (Cardiology), Tokyo Metropolitan Geriatric Hospital.

1988-91 Clinical Fellow, the 3rd Department of Internal Medicine, University of Tokyo.

1991-94 Postdoctoral Fellow, Division of Molecular Genetics, National Institute of Neuroscience, NCNP, Tokyo, Japan.

1994-98 Domestic Research Fellow, Division of Molecular Genetics, National Institute of Neuroscience, NCNP, Tokyo, Japan.

1998-06 Assistant Professor of Pathology, UT Southwestern.

2006- Associate Professor, UT Southwestern.

Education

Graduate SchoolUniversity of Tokyo - Japan (1991)
Graduate SchoolUniversity of Tokyo - Japan, Medicine (1985)

Research Interests

Endocrinology, Endocrine FGF
Molecular Biology of Aging
Nephrology, Mineral metabolism

Publications

Featured
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima Y , Nature , November 1997; (390):45-51

Featured
Suppression of Aging in Mice by the Hormone Klotho

Kurosu H, et al. , Science , August 2005; (309):1829-1833

Regulation of oxidative stress by the anti-aging hormone Klotho

Yamamoto M, et al. , J Biol Chem , September 2005; (280):38029-38034

Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima Y , Nature , November 1997; (390):45-51

Beta-Klotho is required for metabolic activity of fibroblast growth factor 21

Ogawa, Y., Kurosu, H., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Kuro-o, M. , Proc Natl Acad Sci U S A , May 2007; (104):7432-7437

Regulation of fibroblast growth factor-23 signaling by Klotho

Kurosu H et al. , J Biol Chem , March 2006; (281):6120-6123

Suppression of Aging in Mice by the Hormone Klotho

Kurosu H, et al. , Science , August 2005; (309):1829-1833

Honors/Awards

President's Research Council Distinguished Young Researcher Award

UT Southwestern (1999)

Erwin von Belz Preis

Boehringer Ingelheim (1998)

Irvine H. Page Arteriosclerosis Research Awards for Young Investigators

American Heart Association (1997)