Jef De Brabander, PhD

Professor
Endowed Title: Julie and Louis Beecherl Jr. Chair in Medical Science
Biochemistry, Simmons Comprehensive Cancer Center
Graduate Program: Biological Chemistry
Cancer Biology

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-3338
Office Fax: 214-648-8856

jef.debrabander@utsouthwestern.edu

Biography

Jef K. De Brabander is a native of Belgium, where he pursued his undergraduate and graduate studies at the University of Gent. Following postdoctoral studies with the late Wolfgang Oppolzer at the University of Geneva and Paul Wender at Stanford University, he began his independent career as a junior faculty member at the University of Geneva.

After one year, he was recruited to UT Southwestern , where he was promoted to full Professor in 2007. Jef De Brabander was an Alfred P. Sloan Foundation Fellow from 2001-2003, and serves on the Scientific Advisory Board of Reata Pharmaceuticals, a company he co-founded.

Education

Graduate SchoolUniversity of Gent - Belgium, Chemistry (1993)

Research Interests

Integration of molecular pharmacology and biochemistry
Synthesis of complex, naturally occurring, molecular architectures

Publications

Featured
A Small Molecule Smac Mimic Potentiates TRAIL- and TNFa-Mediated Cell Death.

Lin Li, Ranny Mathew Thomas, Hidetaka Suzuki, Jef K. De Brabander, Xiaodong Wang, Patrick G. Harran , Science , September 2004; (305):1471-1474

Featured
Total Synthesis and Structure Revision of the Marine Metabolite Palmerolide A

X. Jiang, B. Liu, S. Lebreton, J. K. De Brabander , Journal of the American Chemical Society , 2007; (129):6386-6387

Featured
Salicylihalamide A inhibits the V0 sector of the V-ATPase through a mechanism distinct from bafilomycin A1.

? Xie X-S, Padron-Perez D, Liao X, Wang J, Roth MG, De Brabander JK , J. Biol. Chem. , 2004; (279):19755-19763

Featured
Total Synthesis and Absolute Configuration of the Novel Microtubule Stabilizing Agent Peloruside A

Liao X, Wu Y, De Brabander JK , Angew. Chem. Int. Ed. , 2003; (42):1648-1652

Featured
Total Synthesis and Initial StructureFunction Analysis of the potent V-ATPase Inhibitors Salicylihalamide A and Related Compounds

Wu Y, Liao X, Wang R, Xie X-S, De Brabander JK , J. Am. Chem. Soc. , 2002; (124):3245-3253

Au(I)- and Pt(II)-Catalyzed Cycloetherification of Omega-Hydroxy Propargylic Esters

J. K. De Brabander, B. Liu, M. Qian , Organic Letters , 2008; (10):2533-2536

Synthesis of Psymberin Analogs: Probing a Functional Correlation with the Pederin/Mycalamide Family of Natural Products.

Jiang, X; Williams, N.; De Brabander, J. K. , Org. Lett. , 2007; (9):227-230

Synthesis of Spirastrellolide A Fragments for Structure Elucidation

Pan, Y.; De Brabander, J. K. , Synlett , 2006; :853-856

Metal-Catalyzed Regioselective Oxy-Functionalization of Internal Alkynes: An Entry into Ketones, Acetals, and Spiroketals.

Liu, B. and De Brabander, J.K. , Org. Lett. , 2006; (8):4907-4010

Synthesis and Complete Stereochemical Assignment of Psymberin / Irciniastatin A. Journal of the American Chemical Society 127, 11254-11255

Jiang, X.; Garcia-Fortanet, J.; De Brabander, J. K. , J. Am. Chem. Soc. , 2005; (127):11254-11255

Honors/Awards

Alfred P. Sloan

Research Fellowship (2001)

Fulbright-Hays

Award (1995)

NATO

Fellowship (1995)

Swiss National Science Foundation

Fellowship (1994)

Institute for Scientific Research in Agriculture and Industry

Scholarship (1989)

Professional Associations/Affiliations

American Association for the Advancement of Science

American Chemical Society