Russell DeBose-Boyd, PhD

Associate Professor
Molecular Genetics
Graduate Program: Biological Chemistry
Cell Regulation

Contact Information

UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, Texas 75390

Office Phone: 214-648-2141
Office Fax: 214-648-8804

russell.debose-boyd@utsouthwestern.edu

Biography

Dr. DeBose-Boyd was born and raised in a small rural southeastern Oklahoma community (population 700) where he graduated from Boswell High School, Boswell, Oklahoma in 1989. Soon thereafter, he began undergraduate studies at Southeastern Oklahoma State University (SOSU) in Durant, OK, where he participated in the Minority Biomedical Research Support program.Dr. DeBose-Boyd obtained a Bachelor of Science degree in Chemistry with minors in Mathematics and Biology in 1993.

Upon completion of undergraduate studies, he was accepted into the Department of Biochemistry and Molecular Biology at the University of Oklahoma Health Sciences Center, and joined the laboratory of Richard D. Cummings, PhD. In 1998, he successfully defended his thesis, entitled "Identification, characterization, and molecular cloning of alpha 1,3 fucosyltransferases in parasitic and non-parasitic helminths."

Following his defense, Dr. DeBose-Boyd joined the laboratory of Joseph L. Goldstein, M.D. and Michael S. Brown, M.D. at UT Soutwestern as a fellow of the Jane Coffin Childs Memorial Fund for Medical Research. Dr. DeBose-Boyd is married to Gwendolyn and has two sons, Reginald and Ryan.

Education

Graduate SchoolUniversity of Oklahoma Health Sciences Center, Biochemistry (1998)
UndergraduateSouthwestern Oklahoma State University, Chemistry (1993)

Research Interests

Cell Regulation
Cholesterol homeostasis
Endoplasmic Reticulum Associated Degradation
Multivalent feedback regulation of HMG CoA reductase

Publications

Featured
Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

Bao-Liang Song, Navdar Sever, and Russell A. DeBose-Boyd , Molecular Cell , September 2005; (19):829-840

Featured
Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol

Bao-Liang Song, Norman B. Javitt, and Russell A. DeBose-Boyd , Cell Metabolism , March 2005; (1):179-189

Featured
Ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase

Bao-Liang Song and Russell A. DeBose-Boyd , Journal of Biological Chemistry , July 2004; (279):28798-28806

Featured
Accelerated Degradation of HMG CoA Reductase Mediated by Binding of Insig-1 to its Sterol-Sensing Domain

Sever, N., Yang, T., Brown, M.S., Goldstein, J.L., and DeBose-Boyd, R.A , Molecular Cell , 2003; (11):25-33

Featured
Transport-dependent proteolysis of SREBP: Relocation of Site-1 Protease from Golgi to ER obviates the need for SREBP transport to Golgi

DeBose-Boyd, R.A., Brown, M.S., Li, W.-P., Nohturfft, A., Goldstein, J.L., and Espenshade, P.J. , Cell , 1999; (99):703-712

Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.

Nguyen, A.D., Lee, S.H., DeBose-Boyd, R.A. , J. Biol. Chem. , September 2009; (284):26778-88

Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase.

Jo, Y., Debose-Boyd, R.A. , Crit. Rev. Biochem. Mol. Biol. , 2010; (45):185-98

Intramembrane glycine mediates multimerization of insig-2, a requirement for sterol regulation in chinese hamster ovary cells.

Lee, P.C., Debose-Boyd, R.A. , J. Lipid Res. , 2010; (51):192-201

Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets.

Hartman, I.Z., Liu, P., Zehmer, J.K., Luby-Phelps, K., Jo, Y., Anderson, R.G., Debose-Boyd, R.A. , J. Biol. Chem. , 2010; (285):19288-98

Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase.

DeBose-Boyd, R.A. , Cell Res. , 2008; (18):609-21

Honors/Awards

Early Career Scientist Award, Howard Hughes Medical Institute

(2009)

W.M. Keck Distinguished Young Scholar in Medical Research

(2006)

David L. Williams Memorial Lectureship Award

(2005)

Established Investigator of American Heart Association

(2005)

Fellow of The Jane Coffin Childs Memorial Fund for Medical Research

(1998)